Janssens et al., Cell 2005
:
PIDD mediates NF-kappaB activation in response to DNA damage ... We now demonstrate that PIDD plays a critical role in DNA-damage induced NF-kappaB activation ... PIDD expression enhances genotoxic-stress induced NF-kappaB activation through augmented sumoylation and ubiquitination of NEMO
Pick et al., Biochem Biophys Res Commun 2006
:
The functional consequences of the identified PIDD/nucleolin interaction remain to be elucidated, but may be related to a recently discovered new role for PIDD in the activation of NF-kappaB upon genotoxic stress