Hu et al., J Biol Chem 1999
(Breast Neoplasms) :
TRAIL-R4 can activate NF-kappaB and protect cells from TRAIL induced apoptosis ... Here we show that TRAIL-R1-, TRAIL-R2-, and TRAIL-R4 induced NF-kappaB activation are mediated by a TRAF2-NIK-IkappaB kinase alpha/beta signaling cascade but is MEKK1 independent
Hasel et al., Lab Invest 2005
(Fibrosis...) :
TRAIL-R4 signaling in T cells induces NFkappaB , which activates antiapoptotic programs
Degli-Esposti et al., Immunity 1997
:
The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL mediated apoptosis, yet retains an incomplete death domain