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MEG3 — TP53

Text-mined interactions from Literome

Zhou et al., J Biol Chem 2007 : Activation of p53 by MEG3 non coding RNA ... Interestingly, MEG3 does not stimulate p21 ( CIP1 ) expression, suggesting that MEG3 can regulate the specificity of p53 transcriptional activation ... We found that MDM2 levels were down-regulated in cells transfected with MEG3, suggesting that MDM2 suppression contributes at least in part to p53 accumulation induced by MEG3
Zhang et al., Endocrinology 2010 (Pituitary Neoplasms) : Expression of MEG3 in tumor cells results in growth suppression, p53 protein increase, and activation of p53 downstream targets
Zhou et al., J Mol Endocrinol 2012 (Neoplasms...) : MEG3 induces accumulation of p53 ( TP53 ) protein, stimulates transcription from a p53 dependent promoter, and selectively regulates p53 target gene expression