Gene interactions and pathways from curated databases and text-mining

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CEBPA — IRF6

Text-mined interactions from Literome

Granger et al., Biochim Biophys Acta 2000 (Kidney Diseases) : Both cell-type- and stimulus-specific regulation of C/EBP mRNA expression and DNA binding activity were identified, with C/EBPalpha being induced by LPS , C/EBPbeta by LPS, IL-1, TNF-alpha and C/EBPdelta by LPS, IL-1, IFN-gamma, TNF-alpha and PDGF
Wang et al., Br J Pharmacol 2001 : LPS also increases the binding activity of C/EBP-alpha and beta, and the response is slower than PAF ... Pretreatment of rats with pyrrolidine dithiocarbamate ( PDTC ) suppresses LPS- , but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF induced C/EBP complex ... These results suggest that PAF and LPS activate intestinal C/EBP in vivo, probably via different pathways
Cho et al., Mol Pharmacol 2003 : Antibody supershift experiments revealed that LPS induced C/EBP DNA binding activity depended on C/EBP beta and C/EBP delta but not C/EBP alpha, C/EBP epsilon or CBP/p300
Kravchenko et al., J Biol Chem 2003 (Inflammation) : Cells lacking IKKi are normal in activation of the canonical NF-kappaB pathway but fail to induce C/EBPdelta activity and transcription of C/EBP and C/EBP-NF-kappaB target genes in response to LPS
Won et al., J Neurosci 2003 : The induction of C/EBP DNA binding activity by LPS and glucose was attributable mainly to the increase in C/EBP-delta protein
Ejarque-Ortiz et al., J Neurosci Res 2007 (Encephalitis...) : This effect is elicited by LPS concentrations > /=100 pg/ml. LPS induced C/EBPalpha down-regulation occurs in microglial cells both in mixed glial and in microglial enriched cultures
Pan et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 (Leukemia, Promyelocytic, Acute) : It is concluded that during ATRA induced APL cell differentiation, IRF-1 is first upregulated by ATRA, and then IRF-1 increases the protein levels of IRF-9 and STAT2 with the downregulation of C/EBPalpha
Wu et al., Biochem Biophys Res Commun 2011 (Inflammation) : Further, we analyzed the effect of LPS on the DNA binding activity of NF-?B, C/EBP and AP-1 transcription factors in liver and lung from WT and AhR ( -/- ) mice
Udofa et al., PloS one 2013 : Electrophoretic mobility shift ( EMSA ) and chromatin immunoprecipitation ( ChIP ) assays demonstrated that LPS induces the formation of C/EBP-ß containing complexes with the SerpinB2 promoter
Eastman et al., Shock 1996 (Acute-Phase Reaction) : Both hypothalamic-pituitary-adrenal axis manipulations resulted in a reduction of the acute phase response as assessed by the LPS mediated induction of acute phase proteins and C/EBP gene expression, with dexamethasone treatment exhibiting a greater inhibitory effect than adrenalectomy
Ray et al., DNA Cell Biol 1997 (Inflammation) : LPS , on the other hand, activated NF-kappaB and C/EBP , which were detected only at the early phase of induction process
Yiangou et al., Biochim Biophys Acta 1998 : As with LPS, the C/EBP beta mRNA levels increased, while the C/EBP alpha mRNA levels decreased in response to LPS