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CEBPA — IRF6
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Granger et al., Biochim Biophys Acta 2000
(Kidney Diseases) :
Both cell-type- and stimulus-specific regulation of C/EBP mRNA expression and DNA binding activity were identified, with
C/EBPalpha being
induced by
LPS , C/EBPbeta by LPS, IL-1, TNF-alpha and C/EBPdelta by LPS, IL-1, IFN-gamma, TNF-alpha and PDGF
Wang et al., Br J Pharmacol 2001
:
LPS also
increases the binding activity of
C/EBP-alpha and beta, and the response is slower than PAF ... Pretreatment of rats with pyrrolidine dithiocarbamate ( PDTC ) suppresses
LPS- , but not PAF-,
induced NF-kappaB and
C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF induced C/EBP complex ... These results suggest that PAF and
LPS activate intestinal
C/EBP in vivo, probably via different pathways
Cho et al., Mol Pharmacol 2003
:
Antibody supershift experiments revealed that
LPS induced
C/EBP DNA binding activity depended on C/EBP beta and C/EBP delta but not C/EBP alpha, C/EBP epsilon or CBP/p300
Kravchenko et al., J Biol Chem 2003
(Inflammation) :
Cells lacking IKKi are normal in activation of the canonical NF-kappaB pathway but fail to induce C/EBPdelta activity and transcription of
C/EBP and C/EBP-NF-kappaB target genes in
response to
LPS
Won et al., J Neurosci 2003
:
The
induction of
C/EBP DNA binding activity by
LPS and glucose was attributable mainly to the increase in C/EBP-delta protein
Ejarque-Ortiz et al., J Neurosci Res 2007
(Encephalitis...) :
This effect is elicited by LPS concentrations > /=100 pg/ml.
LPS induced
C/EBPalpha down-regulation occurs in microglial cells both in mixed glial and in microglial enriched cultures
Pan et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010
(Leukemia, Promyelocytic, Acute) :
It is concluded that during ATRA induced APL cell differentiation,
IRF-1 is first upregulated by ATRA, and then IRF-1
increases the protein levels of IRF-9 and STAT2 with the downregulation of
C/EBPalpha
Wu et al., Biochem Biophys Res Commun 2011
(Inflammation) :
Further, we analyzed the
effect of
LPS on the DNA binding activity of NF-?B,
C/EBP and AP-1 transcription factors in liver and lung from WT and AhR ( -/- ) mice
Udofa et al., PloS one 2013
:
Electrophoretic mobility shift ( EMSA ) and chromatin immunoprecipitation ( ChIP ) assays demonstrated that
LPS induces the formation of
C/EBP-ß containing complexes with the SerpinB2 promoter
Eastman et al., Shock 1996
(Acute-Phase Reaction) :
Both hypothalamic-pituitary-adrenal axis manipulations resulted in a reduction of the acute phase response as assessed by the
LPS mediated induction of acute phase proteins and
C/EBP gene expression, with dexamethasone treatment exhibiting a greater inhibitory effect than adrenalectomy
Ray et al., DNA Cell Biol 1997
(Inflammation) :
LPS , on the other hand,
activated NF-kappaB and
C/EBP , which were detected only at the early phase of induction process
Yiangou et al., Biochim Biophys Acta 1998
:
As with LPS, the C/EBP beta mRNA levels increased, while the
C/EBP alpha mRNA levels decreased in
response to
LPS