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MECOM — TGFB1

Text-mined interactions from Literome

Sood et al., Leukemia 1999 (Translocation, Genetic) : MDS1/EVI1 enhances TGF-beta1 signaling and strengthens its growth-inhibitory effect but the leukemia associated fusion protein AML1/MDS1/EVI1 , product of the t ( 3 ; 21 ), abrogates growth-inhibition in response to TGF-beta1
Nanjundan et al., Cancer Res 2007 (Ovarian Neoplasms) : EVI1 and MDS1/EVI1 gene products increased cell proliferation, migration, and decreased transforming growth factor-beta mediated plasminogen activator inhibitor-1 promoter activity in ovarian epithelial cells
Su et al., Tumori 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : However, specific histone deacetylase inhibitors can interrupt the effect of histone deacetylase to alleviate EVI1 mediated suppression of TGF-beta1/SMAD signaling