◀ Back to TGFB1
TGFB1 — THBS1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
TGFB1
→
THBS1
(increases)
Wang et al., Diabetes 2003*
Evidence: We previously showed that high glucose upregulates thrombospondin 1 (TSP1)-dependent transforming growth factor (TGF)-beta activation by altering cGMP-dependent protein kinase (PKG) activity as a result of decreased nitric
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TGFB1
—
THBS1
(association, biochemical)
Murphy-Ullrich et al., Mol Biol Cell 1992*
-
IRef Hprd Interaction:
TGFB1
—
THBS1
(in vivo)
Murphy-Ullrich et al., Mol Biol Cell 1992*
-
IRef Intact Interaction:
TGFB1
—
THBS1
(direct interaction, solid phase assay)
Seki et al., Nat Genet 2005*
-
IRef Intact Interaction:
Complex of THBS1-CILP-TGFB1
(association, solid phase assay)
Seki et al., Nat Genet 2005*
-
IRef Ophid Interaction:
TGFB1
—
THBS1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
TGFB1
—
THBS1
(aggregation, confirmational text mining)
Murphy-Ullrich et al., Mol Biol Cell 1992*
Text-mined interactions from Literome
Claisse et al., J Cell Sci 1999
:
TGF-beta1 strongly
activated the production of
thrombospondin-1 and ( alpha)vbeta3 integrin in a concentration dependent manner whereas the expression of thyroglobulin was unaffected
Abdelouahed et al., J Biol Chem 2000
:
Thrombospondin-1 (TSP-1) has been shown to bind and
activate transforming growth factor-beta1 ( TGF-beta1 )
Grainger et al., Biochem J 2000
:
Thrombospondin 1 does not
activate transforming growth factor beta1 in a chemically defined system or in smooth-muscle-cell cultures
Yevdokimova et al., J Am Soc Nephrol 2001
:
Thrombospondin-1 is the key
activator of
TGF-beta1 in human mesangial cells exposed to high glucose
Sasaki et al., Neurol Med Chir (Tokyo) 2001
(Brain Neoplasms...) :
Participation of
thrombospondin-1 in the activation of latent
transforming growth factor-beta in malignant glioma cells
Okamoto et al., Biochim Biophys Acta 2002
(Bone Neoplasms...) :
Up-regulation of
thrombospondin-1 gene by epidermal growth factor and
transforming growth factor beta in human cancer cells -- transcriptional activation and messenger RNA stabilization
Miyanaga et al., Anticancer Res 2002
(Colorectal Neoplasms...) :
Thrombospondin-1 (TSP1) inhibits angiogenesis and
activates transforming growth factor beta-1 ( TGF beta-1 )
Wang et al., Diabetes 2003
(Diabetic Nephropathies...) :
We previously showed that high glucose upregulates
thrombospondin 1 (TSP1) dependent
transforming growth factor ( TGF ) -beta activation by altering cGMP dependent protein kinase ( PKG ) activity as a result of decreased nitric oxide signaling
Janat et al., J Cell Physiol 1992
:
We have studied the
effect of
transforming growth factor beta 1 ( TGF-beta 1 ) on vascular smooth muscle cell ( SMC ) mitogenesis and expression of
thrombospondin and other growth related genes ... Although
TGF-beta 1 was able to directly
enhance expression of
thrombospondin as well as the growth related genes c-fos and c-myc, and induced c-fos expression with identical kinetics as PDGF, it was unable to elicit [ 3H ] thymidine incorporation into DNA in three independent smooth muscle cell strains ... Our results strongly suggest that
induction of
thrombospondin expression by
TGF-beta 1 and by PDGF occurs by distinct mechanisms ... In addition, that TGF-beta 1 can enhance PDGF induced mitogenesis may be due to the ability of
TGF-beta 1 to directly
induce the expression of
thrombospondin , c-fos, c-myc, and the PDGF beta-receptor
Kondou et al., J Hepatol 2003
(Atrophy...) :
Thrombospondin-1 is a major activator of transforming growth factor-beta1 ( TGF-beta1 ), and a peptide derived from the latency associated peptide, Leu-Ser-Lys-Leu ( LSKL ),
inhibits the activation of
TGF-beta1
Horiguchi et al., Endocrine 2004
:
Regulation of VEGF-A, VEGFR-I,
thrombospondin-1 , -2, and -3 expression in a human pituitary cell line ( HP75 ) by
TGFbeta1 , bFGF, and EGF
Jou et al., Arthritis Rheum 2005
(Arthritis, Experimental) :
Because
thrombospondin 1 (TSP-1) inhibits angiogenesis and
activates latent
transforming growth factor beta ( TGFbeta ), a potent immunosuppressive and antiinflammatory cytokine, we investigated the prophylactic and therapeutic effects of TSP-1 gene transfer in the collagen induced arthritis ( CIA ) model in rats
Nakagawa et al., J Am Soc Nephrol 2005
:
Role of ERK1/2 and p38 mitogen activated protein kinases in the
regulation of
thrombospondin-1 by
TGF-beta1 in rat proximal tubular cells and mouse fibroblasts ...
Thrombospondin-1 (TSP-1) inhibits angiogenesis and
activates latent
TGF-beta1 , both of which are strongly associated with progression of renal disease
Breitkopf et al., Gut 2005
:
Thrombospondin 1 (TSP-1) is an important
activator of latent
transforming growth factor beta ( TGF-beta ) but little is known of the expression patterns and functions of TSP-1 in liver cells
Mimura et al., Am J Pathol 2005
(Scleroderma, Systemic) :
Constitutive
thrombospondin-1 overexpression
contributes to autocrine
transforming growth factor-beta signaling in cultured scleroderma fibroblasts
Sakamoto et al., Atherosclerosis 2005
(Atherosclerosis) :
Specific interaction of oxidized low-density lipoprotein with
thrombospondin-1 inhibits
transforming growth factor-beta from its activation
Li et al., Kidney Int 2005
:
1,25 ( OH ) ( 2 ) D ( 3 ) also suppressed type I collagen and
thrombospondin-1 expression
induced by
TGF-beta1
Wahab et al., Diabetologia 2005
(Diabetes Mellitus, Type 1...) :
In contrast to high-glucose conditions, increases in fibronectin synthesis that were stimulated by glycated albumin were not dependent on
THBS1 activation of latent
TGFB1
McGillicuddy et al., Vascul Pharmacol 2006
(Coronary Restenosis...) :
TGF-beta1 induced
thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells
Yevdokimova et al., Acta biochimica Polonica 2006
:
The involvement of
transforming growth factor beta1 and its
activation by
thrombospondin-1
Myung et al., Biochem Biophys Res Commun 2007
:
Bile acid mediated
thrombospondin-1 induction in hepatocytes
leads to
transforming growth factor-beta dependent hepatic stellate cell activation
Chen et al., Exp Toxicol Pathol 2009
(Disease Models, Animal...) :
Thrombospondin-1(TSP-1) was
involved in the activation of latent
TGF-beta1 ( L-TGF-beta1 ) through the association of the TSP-1/L-TGF-beta1 complex with the cell receptor of TSP-1, CD36
Ide et al., Respir Med 2008
(Idiopathic Interstitial Pneumonias) :
Thrombospondin-1 (TSP-1) , a multifunctional matricellular glycoprotein, can
activate transforming growth factor-beta , an important profibrotic cytokine involved in various fibrotic diseases
Ahamed et al., PloS one 2009
(Disease Models, Animal...) :
In vitro and in vivo evidence that
thrombospondin-1 (TSP-1) contributes to stirring- and shear dependent activation of platelet derived
TGF-beta1 ...
Thrombospondin 1 (TSP-1) , which is contained in platelet alpha-granules and released with activation, has been shown to
activate latent
TGF-beta1 in vitro, but its in vivo role is unclear as TSP-1-null ( Thbs1 ( -/- ) ) mice have a much less severe phenotype than TGF-beta1-null ( Tgfb1 ( -/- ) ) mice
Turpie et al., Am J Pathol 2009
(Disease Models, Animal...) :
Thrombospondin-1 (TSP-1) is a major
activator of latent
transforming growth factor-beta in vitro as well as in vivo
Schultz-Cherry et al., J Biol Chem 1994
:
Thrombospondin binds and
activates the small and large forms of latent
transforming growth factor-beta in a chemically defined system
Schultz-Cherry et al., J Cell Biol 1993
:
Thrombospondin causes activation of latent
transforming growth factor-beta secreted by endothelial cells by a novel mechanism
Hsu et al., Cancer Res 1996
(Brain Neoplasms...) :
This change in angiogenesis was directly due to the increased secretion of a potent inhibitor of angiogenesis, thrombospondin-1, because : ( a ) neutralizing thrombospondin completely relieved the inhibition ; ( b ) the inhibitory activity of
thrombospondin was not
dependent on
transforming growth factor beta ; and ( c ) chromosome 10 introduction did not alter secreted inducing activity
Jakowlew et al., Biochim Biophys Acta 1997
(Carcinoma, Non-Small-Cell Lung...) :
To investigate the relationship between plasminogen activator (PA), plasminogen activator inhibitor-1 ( PAI-1 ) and the extracellular matrix in malignant and normal lung epithelial cells and to determine whether malignant lung epithelial cells may be more invasive than normal lung epithelial cells because of differences in expression of these proteins in response to TGF-beta, the
regulation of PA, PAI-1, fibronectin, laminin and
thrombospondin by
TGF-beta1 in human non-small cell lung cancer ( NSCLC ) cells was examined and compared with normal human bronchial epithelial ( NHBE ) cells
Crawford et al., Cell 1998
:
Thrombospondin-1 is a major
activator of
TGF-beta1 in vivo
Basile et al., Curr Opin Nephrol Hypertens 1999
(Kidney Diseases) :
Both in-vitro and in-vivo studies have demonstrated that proteolytic activity,
thrombospondin-1 , elevated glucose, angiotensin II, oxidant stress and hemodynamic forces
regulate transforming growth factor beta activity through both transcriptional and post-transcriptional mechanisms ... Both in-vitro and in-vivo studies have demonstrated that proteolytic activity,
thrombospondin-1 , elevated glucose, angiotensin II, oxidant stress and hemodynamic forces
regulate transforming growth factor beta activity through both transcriptional and post-transcriptional mechanisms