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FGF2 — IL6

Text-mined interactions from Literome

Delrieu et al., Biochem J 1999 : Furthermore, 24 kDa FGF-2 inhibits the activity of both the co-transfected deletion mutants IL-6 ( -224 ) and IL-6 ( -158 ), and the point mutated IL-6 promoter constructs in which the activating protein-1, nuclear factor (NF)-IL-6 and NF-kappaB elements are disrupted
Bodo et al., Eur J Cell Biol 1999 (Craniofacial Dysostosis) : ELISA showed that bFGF induced interleukin secretion differed in normal and Crouzon osteoblasts
Kozawa et al., J Cell Biochem 1999 : Involvement of p38 mitogen activated protein kinase in basic fibroblast growth factor induced interleukin-6 synthesis in osteoblasts ... In the present study, we further investigated the mechanism underlying the bFGF induced IL-6 synthesis in MC3T3-E1 cells ... SB203580, a specific inhibitor of p38 MAP kinase, suppressed the bFGF induced IL-6 synthesis dose-dependently ... 1-Oleoyl-2-acetyl-sn-glycerol, a synthetic diacylglycerol activating PKC, reduced the bFGF induced IL-6 synthesis ... These results strongly suggest that bFGF induced IL-6 synthesis is mediated via p38 MAP kinase activation in osteoblasts, and that PKC acts at a point upstream from p38 MAP kinase
Fima et al., Eur Cytokine Netw 1999 (MAP Kinase Signaling System) : The effects of FGF and PDGF on IL-6 production were blocked in the presence of PKC inhibitors
Kozawa et al., Cell Signal 2002 : Leukemia inhibitory factor enhances bFGF induced IL-6 synthesis in osteoblasts : involvement of JAK2/STAT3 ... On the contrary, LIF, which alone had little effect on IL-6 release, significantly enhanced the bFGF stimulated IL-6 release
Penkowa et al., J Neurosci Res 2003 (Disease Models, Animal...) : Also, IL-6 induced significant increases in proinflammatory cytokines IL-1, IL-12, and tumor necrosis factor-alpha as well as growth factors basic fibroblast growth factor (bFGF) , transforming growth factor-beta, neurotrophin-3, angiopoietin, vascular endothelial growth factor, and the receptor for bFGF
Jee et al., J Invest Dermatol 2004 (Carcinoma, Basal Cell...) : The level of basic fibroblast growth factor 2 ( bFGF ) mRNA and secreted bFGF increased in IL-6 overexpressing BCC cells as shown by RT-PCR and ELISA, respectively
Im et al., J Biol Chem 2007 : bFGF stimulation of MMP-13 was mediated at the transcriptional level and, at least in part, by stimulation of interleukin-1 production
Ulbrich et al., J Cell Biochem 2008 : After 24 h micro g, bFGF elevated fibronectin, Flk-1 and Flt-1 protein, and reduced IL-6 and IL-8 compared with vehicle treated micro g cultures
Takai et al., J Endocrinol 2008 : To further clarify the mechanism underlying the synthesis of IL-6 in osteoblasts, we investigated whether p70 S6 kinase is involved in the FGF-2 stimulated IL-6 synthesis in these cells ... Rapamycin, an inhibitor of p70 S6 kinase, significantly enhanced the FGF-2 stimulated IL-6 synthesis in a dose dependent manner ... Downregulation of p70 S6 kinase by siRNA markedly amplified the FGF-2 stimulated IL-6 synthesis ... These results strongly suggest that p70 S6 kinase functions at a point downstream of protein kinase C and limits the FGF-2 stimulated IL-6 synthesis in osteoblasts
Tokuda et al., Horm Metab Res 2008 : ( - ) -Epigallocatechin gallate inhibits basic fibroblast growth factor stimulated interleukin-6 synthesis in osteoblasts ... We previously showed that basic fibroblast growth factor ( FGF-2 ) activates the mitogen activated protein ( MAP ) kinase superfamily in osteoblast-like MC3T3-E1 cells and that p38 MAP kinase functions as a positive regulator in the FGF-2 stimulated synthesis of interleukin-6 (IL-6) , a potent bone-resorptive agent, in these cells ... PD98059, an inhibitor of MEK, but not SP600125, an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase, suppressed FGF-2 stimulated IL-6 synthesis ... These results strongly suggest that EGCG inhibits the FGF-2 stimulated synthesis of IL-6 at least partly via suppression of the p44/p42 MAP kinase pathway and the p38 MAP kinase pathway in osteoblasts
Sandell et al., Osteoarthritis Cartilage 2008 (Arthritis) : In the presence of IL-1beta, FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1, CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6 , and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Guerne et al., J Immunol 1990 : fibroblast growth factor , insulin growth factor-1 and 2, platelet growth factor or insulin, was able to significantly increase IL-6 synthesis
Yan et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : Mechanistically, LfcinB attenuated the effects of IL-1ß and FGF-2 on the expression of cartilage degrading enzymes ( MMP-1, MMP-3, and MMP-13 ), destructive cytokines ( IL-1ß and IL-6 ), and inflammatory mediators ( iNOS and TLR2 )
Ben Jemaa et al., Inflammation 2013 : bFGF enhances IL-6 production in LNCaP and PC3-PSMA prostate cancer cells ... The effect of bFGF on stimulating IL-6 secretion was greater in LNCaP than in PC3-PSMA cells
Chandrasekhar et al., J Cell Physiol 1989 : Induction of interleukin-1 receptors on chondrocytes by fibroblast growth factor : a possible mechanism for modulation of interleukin-1 activity
Iwamoto et al., Immunol Lett 1989 : Furthermore, interleukin 1 (IL-1) suppressed by 50-60 % the incorporation of [ 3H ] thymidine into DNA in high density chondrocyte cultures on plastic dishes in the presence of 10 % serum or fibroblast growth factor , although it increased twofold this incorporation in 0.3 % serum alone
Norioka et al., Jpn J Cancer Res 1994 (Neovascularization, Pathologic) : Interaction of interleukin-1 and interferon-gamma on fibroblast growth factor induced angiogenesis
Dooley et al., J Cell Physiol 1995 : Basic FGF did not reduce the levels of interleukin-6 (IL-6) , GM-CSF, or G-CSF released by steady state or IL-1 stimulated stroma
Berardi et al., Blood 1995 : To address the direct effects of FGF, we investigated whether FGF induced production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha, IL-6 , granulocyte colony stimulating factor, or granulocyte-macrophage colony stimulating factor by two types of accessory cells, bone marrow ( BM ) fibroblasts and macrophages
Wu et al., J Biol Chem 1996 : Mechanistically, NGF and bFGF induce a sustained phosphorylation and activation of ERK1 and ERK2 in both cells, while IL-6 produces only a transient and weak tyrosine phosphorylation
Hurley et al., J Bone Miner Res 1996 : Regulation of NFIL-6 and IL-6 expression by basic fibroblast growth factor in osteoblasts ... We determined whether basic fibroblast growth factor (bFGF) regulated the expression of IL-6 and NFIL-6 in osteoblasts
Tamura et al., Endocrinology 1996 (Arthritis...) : Nitric oxide mediates interleukin-1 induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes : a possible mechanism of pathological neovascularization in arthritis
Nakamura et al., J Hypertens 1996 : bFGF , TGF-beta, interleukin-1 alpha, -1 beta and -6 stimulated DNA synthesis in VSMC significantly, whereas HGF did not
Kozawa et al., Cell Signal 1997 : Basic fibroblast growth factor induces interleukin-6 synthesis in osteoblasts : autoregulation by protein kinase C ... In this study, we investigated the effect of bFGF on interleukin-6 (IL-6) synthesis in these cells ... bFGF stimulated the IL-6 synthesis dose-dependently in the range between 1 and 30 ng/ml ... The depletion of extracellular Ca2+ by EGTA suppressed the bFGF induced IL-6 synthesis ... Staurosporine, an inhibitor for protein kinases, enhanced the bFGF induced IL-6 synthesis ... The bFGF induced IL-6 synthesis was amplified in PKC down-regulated cells ... U-73122, a phospholipase C inhibitor, enhanced the bFGF induced IL-6 synthesis
Sasaki et al., J Biochem 1998 : Nitric oxide mediates interleukin-1 induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes