Fonsato et al., Am J Pathol 2006
(Kidney Neoplasms...) :
The inhibition of Pax2 expression in tumor derived endothelial cells induced an increase in tumor suppressor PTEN expression and a decrease in Akt phosphorylation
Zhang et al., J Am Soc Nephrol 2007
:
This occurs, at least in part, via reactive oxygen species generation, activation of Akt signaling, and upregulation of Pax-2 gene expression