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EPHB2 — TREM2
Text-mined interactions from Literome
Bouchon et al., J Immunol 2000
(Calcium Signaling...) :
Intracellularly,
TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal related kinase 1 ( ERK1 ),
ERK2 and phospholipase C-gamma
Peng et al., Science signaling 2010
:
Here, we demonstrate that the ligation of
TREM2 activated phosphatidylinositol 3-kinase (PI3K), extracellular signal regulated kinase 1 ( ERK1 ) and
ERK2 , and the guanine nucleotide exchange factor Vav3 ; induced the mobilization of intracellular calcium ( Ca ( 2+ ) ) and the reorganization of actin ; and prevented apoptosis