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AKT1 — CD79A

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 1999 : In this study, we demonstrate that ligation of B cell antigen receptor (BCR) leads to activation of Akt/PKB in B lymphocytes ... In this study, we demonstrate that ligation of B cell antigen receptor (BCR) leads to activation of Akt/PKB in B lymphocytes ... BCR induced activation of Akt/PKB required the tyrosine kinase Syk, which was not previously known to regulate Akt/PKB ... BCR induced activation of Akt/PKB required the tyrosine kinase Syk, which was not previously known to regulate Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on BCR mediated activation of Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on BCR mediated activation of Akt/PKB
Astoul et al., J Cell Biol 1999 : Membrane translocation of PKB and subsequent PKB activation are dependent on BCR activation of phosphatidylinositol 3-kinase (PI3K)
Craxton et al., J Biol Chem 1999 : Increased BCR induced Akt phosphorylation was observed in Lyn-deficient DT40 cells and Lyn ( -/- ) mice compared with wild-type cells suggesting that Lyn may negatively regulate Akt function
Voss et al., Oncogene 2000 (MAP Kinase Signaling System...) : The mitogenic MAPK/Erk kinases as well as Akt/PKB , a kinase implicated to negatively regulate apoptosis, were also constitutively activated by both Bcr-Abl and Tel-Abl ... The mitogenic MAPK/Erk kinases as well as Akt/PKB , a kinase implicated to negatively regulate apoptosis, were also constitutively activated by both Bcr-Abl and Tel-Abl
Christian et al., J Biol Chem 2003 : Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway, expressing constitutively active Rap2 ( Rap2V12 ) reduced BCR induced phosphorylation of Akt and FKHR
Kövesdi et al., Cell Signal 2004 (MAP Kinase Signaling System) : We have detected a short lived BCR-driven activation of mitogen activated protein kinases ( ERK1/2 and p38 MAPK ) and Akt/PKB in transitional immature B cells that correlated with the lack of c-Fos expression, reduced phosphorylation of Akt substrates and a susceptibility for apoptosis
Tybulewicz et al., Eur J Immunol 2004 (Second Messenger Systems) : Unexpectedly, they show that while the BCR induced phosphorylation of the PI3K dependent kinase Akt is reduced in p85alpha-deficient cells, the phosphorylation of two downstream targets of Akt -- FOXO1 and ribosomal protein S6 -- is largely unaffected
Barnes et al., Oncogene 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Both IL-3 treatment and expression of Bcr-Abl led to enhanced phosphorylation of Akt ( protein kinase B )
Xing et al., J Exp Med 2005 : G5pr(-/-) B cells did not show abnormalities in the BCR mediated activation of Erks and NF-kappaB, cyclin D2 induction, or Akt activation
Bilancio et al., Blood 2006 : p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB) , forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk )
Chu et al., Cancer Res 2007 (Cell Transformation, Neoplastic...) : BCR/ABL expression results in enhanced Ras and Akt activity but reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation
Lee et al., Journal of cell communication and signaling 2007 : In contrast, BCR induced activation of ERK, JNK, p38, and Akt was not affected by ROS depletion
Gobessi et al., Leukemia 2009 (Leukemia, Lymphocytic, Chronic, B-Cell) : In addition, R406 prevented the increase in leukemic cell viability induced by sustained BCR engagement and inhibited BCR induced Akt activation and Mcl-1 upregulation
Hirano et al., J Biol Chem 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1 , -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells
Quiroga et al., Blood 2009 (Leukemia, Lymphocytic, Chronic, B-Cell) : Finally, R406 inhibited constitutive and BCR induced activation of Syk, extracellular signal regulated kinases, and AKT , and blocked BCR induced calcium mobilization
Oak et al., Autoimmunity 2009 : BCR mediated AKT phosphorylation is partially reduced in p85alpha-deficient B cells and further diminished with concomitant loss of p85beta
Taniguchi et al., PloS one 2013 : Here, we present data indicating that the increase in intracellular zinc level induced by ZIP9/SLC39A9 ( a ZIP Zrt-/Irt-like protein ) plays an important role in the activation of Akt and Erk in response to BCR activation