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AKT1 — F2R

Text-mined interactions from Literome

Sabri et al., Circ Res 2002 : Activation of PAR-1 leads to an increase in Src, Fyn, and epidermal growth factor receptor (EGFR) phosphorylation, with EGFR receptor transactivation by Src family kinases the major mechanism for PAR-1 dependent activation of extracellular signal regulated kinase, p38-mitogen activated protein kinase, and protein kinase B ... PAR-1 signaling is highly contextual in nature, inasmuch as PAR-1 activates extracellular signal regulated kinase and only weakly stimulates protein kinase B via a pathway that does not involve EGFR transactivation in cardiomyocytes
Salah et al., Mol Cancer Res 2007 (Disease Progression...) : The activation of PAR1 induced pAkt/protein kinase B abrogated serum deprived Bim ( EL ) induction and also markedly inhibited Bax levels
Reséndiz et al., Journal of thrombosis and haemostasis : JTH 2007 : Stimulation of PAR1 or PAR4 resulted in rapid Akt phosphorylation, independently of secreted ADP and phosphatidylinositol-3-kinase (PI3K) activation
Dickey et al., Proc Natl Acad Sci U S A 2008 (Alzheimer Disease) : Akt enhances the activity of PAR1 to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 complex
Maeda et al., Brain Res 2009 : In addition, Akt phosphorylation caused by plasmin was inhibited in the presence of PAR-1 inhibitor