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AKT1 — MAP3K5
Pathways - manually collected, often from reviews:
-
KEGG MAPK signaling pathway:
AKT1/AKT2/AKT3
→
MAP3K5
(protein-protein, inhibition)
-
NCI Pathway Database Class I PI3K signaling events mediated by Akt:
AKT1/ASK1 complex (AKT1-MAP3K5)
→
AKT1 (AKT1)
(modification, collaborate)
Kim et al., Mol Cell Biol 2001*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Class I PI3K signaling events mediated by Akt:
AKT1/ASK1 complex (AKT1-MAP3K5)
→
ASK1 (MAP3K5)
(modification, collaborate)
Kim et al., Mol Cell Biol 2001*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Class I PI3K signaling events mediated by Akt:
AKT1 (AKT1)
→
ASK1 (MAP3K5)
(modification, collaborate)
Kim et al., Mol Cell Biol 2001*
Evidence: mutant phenotype, assay, physical interaction
-
WikiPathways MAPK Signaling Pathway:
AKT1/AKT2/AKT3
→
MAP3K5
(mim-inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAP3K5
—
AKT1
(physical association, affinity chromatography technology)
Kim et al., Mol Cell Biol 2001*
-
IRef Biogrid Interaction:
MAP3K5
—
AKT1
(direct interaction, enzymatic study)
Kim et al., Mol Cell Biol 2001*
-
IRef Hprd Interaction:
MAP3K5
—
AKT1
(in vivo)
Kim et al., Mol Cell Biol 2001*
-
IRef Hprd Interaction:
MAP3K5
—
AKT1
(in vitro)
Kim et al., Mol Cell Biol 2001*
-
IRef Innatedb Interaction:
MAP3K5
—
AKT1
(unknown, -)
Kim et al., Mol Cell Biol 2001*
-
IRef Intact Interaction:
MAP3K5
—
AKT1
(phosphorylation reaction, protein kinase assay)
Kim et al., Mol Cell Biol 2001*
-
IRef Intact Interaction:
MAP3K5
—
AKT1
(phosphorylation reaction, anti bait coimmunoprecipitation)
Kim et al., Mol Cell Biol 2001*
Text-mined interactions from Literome
Kim et al., Mol Cell Biol 2001
:
Akt phosphorylates and negatively
regulates apoptosis signal regulating kinase 1
Ling et al., Biochem J 2004
(Inflammation) :
The suppressive effects of HC-gp39 were dependent on phosphoinositide 3-kinase activity, and treatment of cells with HC-gp39 resulted in
AKT mediated serine/threonine phosphorylation of
apoptosis signal regulating kinase 1
Yang et al., Cell Microbiol 2006
(MAP Kinase Signaling System) :
Furthermore, the inhibition of
PI3K-Akt , but not ERK 1/2 pathway, attenuated M. tbc
induced S6K1 phosphorylation, whereas PI3K inhibition enhanced p38 phosphorylation and
apoptosis signal regulating kinase 1 activity during exposure to M. tbc
Widenmaier et al., J Biol Chem 2009
:
Suppression of p38 MAPK and JNK via
Akt mediated inhibition of
apoptosis signal regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose dependent insulinotropic polypeptide ... Inhibition of apoptosis by GIP is therefore mediated via a key pathway involving
Akt dependent inhibition of
apoptosis signal regulating kinase 1 , which subsequently prevents the pro-apoptotic actions of p38 MAPK and JNK