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AGTR2 — STAT3
Text-mined interactions from Literome
Horiuchi et al., Circ Res 1999
:
In the present study, we report that the stimulation of
AT2 receptor in AT2 receptor cDNA transfected rat adult vascular smooth muscle cells ( VSMCs )
inhibited angiotensin II type 1 (AT1) receptor mediated tyrosine phosphorylation of STAT ( signal transducers and activators of transcription ) 1alpha/beta, STAT2, and
STAT3 without influence on Janus kinase ... Moreover,
AT2 receptor
inhibited serine phosphorylation of STAT1alpha and
STAT3 via the inhibition of extracellular signal regulated kinase ( ERK ) activation
Abadir et al., J Interferon Cytokine Res 2011
(Inflammation) :
Further,
AT(2)R activation
reduced TNF-a production by 39 % and
STAT3 phosphorylation by 83 %