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IL2 — MBP

Text-mined interactions from Literome

Mannie et al., Cell Immunol 1992 (Encephalomyelitis, Autoimmune, Experimental...) : First, RS-NAdh SPL were required by THYB-2 hybrids for MBP stimulated IL-2 production but were not needed when MBP-specific inhibition of hybrid growth was used as an alternative measure of cellular activation
Karpus et al., Eur J Immunol 1992 (Encephalomyelitis, Autoimmune, Experimental) : CD4+ Ts do not proliferate or secrete IFN-gamma, IL-2 , or IL-4 in response to myelin basic protein , nor do CD4+ Ts proliferate or secrete IL-2 when co-cultured with irradiated EAE effector cells
Whitacre et al., J Immunol 1991 (Encephalomyelitis, Autoimmune, Experimental) : Thus, because lymphocytes from MBP fed rats neither proliferate nor secrete IL-2 or IFN-gamma in response to MBP and we can find no compelling evidence for the role of suppressor cells, we propose that the oral administration of MBP results in a state of clonal anergy
Selmaj et al., Clin Exp Immunol 1988 (Multiple Sclerosis) : Multiple sclerosis : effect of myelin basic protein on interleukin 1, interleukin 2 production and interleukin 2 receptor expression in vitro ... Myelin basic protein significantly increased both IL-1 and IL-2 production by PBMC from MS patients during relapse when compared to OND patients or healthy controls
Mannie et al., J Immunol 1993 (Encephalomyelitis, Autoimmune, Experimental) : Studies focusing on two CD4+ T cell hybridomas revealed that W3/25 profoundly inhibited MBP stimulated IL-2 production but did not affect the alternative response of MBP induced growth inhibition ... Several other hybrids also mediated MBP stimulated IL-2 production but did not express CD4 and were not affected by W3/25
Mannie et al., Cell Immunol 1994 (Encephalomyelitis, Autoimmune, Experimental) : The LRTC1 mAb inhibited MBP stimulated IL-2 production by THYB-2 hybrids but not by THYB-1 hybrids and did not inhibit the alternative response of MBP induced growth inhibition by either hybrid subset ... LRTC1 inhibited MBP stimulated IL-2 production by GP2.E5 T cells but did not effectively block MBP stimulated proliferation
Mannie et al., Immunol Lett 1993 (Encephalomyelitis, Autoimmune, Experimental) : However, THYB-2 hybrids uniquely express additional requirements for co-stimulatory signals from radiosensitive splenocytes ( SPL ) to support the response of MBP stimulated IL-2 production
Mannie et al., Cell Immunol 1994 (Encephalomyelitis, Autoimmune, Experimental) : This study shows that T cells reactivated within approximately 7 days of a prior activation were refractory to the reinduction of MBP stimulated IL-2 production ... In cultures of T cells recently activated by MBP in the presence of W3/25, the use of nonirradiated SPL rather than irradiated SPL reversed W3/25 mediated tolerance but did not restore MBP stimulated IL-2 production
Mannie et al., Cell Immunol 1995 : Even after several weeks of propagation in IL-2 containing medium, anergic T cells exhibited marked reductions in MBP stimulated proliferation and IL-2 production responses when restimulated with optimal concentrations of MBP and irradiated splenocytes ( SPL )
Watkins et al., Cell Immunol 1993 (Multiple Sclerosis) : In this study, costimulatory pathways were defined by comparing MBP stimulated IL-2 production by two types of T cell hybridoma ( designated THYB-1 and THYB-2 )
Sun et al., Proc Natl Acad Sci U S A 1996 (Encephalomyelitis, Autoimmune, Experimental...) : Such treatment was as effective in suppressing interleukin 2 production and proliferative responses of lymph node cells to MBP as treatment involving repeated feeding with much larger ( 50- to 100-fold ) doses of free MBP
Arnold et al., Hybridoma 1998 : The purpose of these studies was to identify the ligand for the LRTC1 MAb and to determine whether this MAb affected MBP stimulated IL-2 production and expression of MHC class II molecules by T cells