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PTGS2 — WNT1
Text-mined interactions from Literome
Howe et al., Cancer Res 1999
(Breast Neoplasms...) :
Here, we have investigated the
effect of
Wnt-1 on
cyclooxygenase-2 expression ... Expression of
Wnt-1 in these cells
caused transcriptional up-regulation of the
cyclooxygenase-2 gene, resulting in increased levels of cyclooxygenase-2 mRNA and protein ... In view of the critical role of cyclooxygenase-2 in intestinal tumorigenesis,
cyclooxygenase-2 up-regulation in
response to
Wnt signaling may contribute to Wnt induced mammary carcinogenesis
Rigas et al., Trends Mol Med 2004
(Neoplasms) :
Mechanistically, NO-aspirin, the best studied NO-NSAID, has pleiotropic effects on cell signaling ( it inhibits
Wnt signaling, induces nitric oxide synthase and NF-kappaB activation and
induces cyclooxygenase-2 expression ), and this mechanistic redundancy might be central to its mode of action against cancer
Tuynman et al., Cancer Res 2008
(Colonic Neoplasms) :
Cyclooxygenase-2 inhibition
inhibits c-Met kinase activity and
Wnt activity in colon cancer