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Kang et al., J Biol Chem 2007
(Anoxia) :
Our findings indicate that transient hypoxia ( 1 % oxygen ) leads to caspase mediated cleavage of IRS-1 without inducing cell death
Kim et al., Apoptosis 2009
(Neuroblastoma) :
In the presence of high glucose, IRS-1 underwent caspase mediated degradation, followed by focal adhesion kinase ( FAK ) and Akt degradation and apoptosis