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PTGS2 — VEGFA

Text-mined interactions from Literome

Hernández et al., J Exp Med 2001 : Here we show that CsA inhibits migration of primary endothelial cells and angiogenesis induced by vascular endothelial growth factor ( VEGF ) ; this effect appears to be mediated through the inhibition of cyclooxygenase (Cox)-2 , the transcription of which is activated by VEGF in primary endothelial cells ... Consistent with this, we show that the induction of Cox-2 gene expression by VEGF requires NFAT activation
Murono et al., Proc Natl Acad Sci U S A 2001 (Nasopharyngeal Neoplasms...) : Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells
Ishiko et al., Oncol Rep 2001 (Carcinoma in Situ...) : In conclusion, the expression of COX-2 in ACC may induce the expression of VEGF , increase angiogenesis and enhance tumor growth and invasion
Akarasereenont et al., Mediators Inflamm 2002 : Thus, the induction of COX-2 by VEGF in endothelial cells was mediated through protein tyrosine kinase, and the uses of specific COX-2 inhibitors in these conditions, in which VEGF was involved, might have a role
Tamura et al., J Clin Endocrinol Metab 2002 : Pretreatment of HMEC-1 with a selective COX-2 inhibitor, NS-398, abolished VEGF induced PGE ( 2 ) synthesis, suggesting specific up-regulation of COX-2 activity by VEGF in HMEC-1 ... Transient transfection assays using deletion mutants of the human COX-2 promoter fused to the luciferase reporter gene indicated critical requirement of a regulatory region spanning -828/-123 bp for VEGF induction of COX-2 promoter activity in HMEC-1
Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 also induces vascular endothelial growth factor through cyclooxygenase-2 activation and interleukin-8 through NF-kappaB activation
Ma et al., Proc Natl Acad Sci U S A 2002 (Neovascularization, Pathologic...) : Therefore, we compared the effects of a nonselective COX inhibitor ( flurbiprofen ), a nitric oxide releasing COX inhibitor ( HCT-1026 ), and a selective COX-2 inhibitor ( celecoxib ) on gastric ulcer healing, angiogenesis, and platelet/serum levels of vascular endothelial growth factor ( VEGF ) and endostatin
Liu et al., J Biol Chem 2002 (Anoxia...) : We reported previously that COX-2 inhibition prevents hypoxic up-regulation of VEGF in human prostate cancer cells and that prostaglandin E ( 2 ) ( PGE ( 2 ) ) restores hypoxic effects on VEGF
Eibl et al., Biochem Biophys Res Commun 2003 (Pancreatic Neoplasms) : PGE ( 2 ) is generated by specific COX-2 activity and increases VEGF production in COX-2 expressing human pancreatic cancer cells
Wu et al., Am J Physiol Heart Circ Physiol 2003 (Anoxia...) : COX-2 was significantly induced by VEGF ( 4.86 +/- 1.03-fold ) and IL-1beta ( 3.93 +/- 0.89-fold ) and slightly increased by TNF-alpha but not by FGF2, IGF-1, or PDGFs. Analysis of proteins secreted in HMCM showed increased levels of VEGF but not IL-1 beta or TNF-alpha ... VEGF induced endothelial cell COX-2 expression by both increasing COX-2 transcription and prolonging the COX-2 mRNA half-life ... Both a selective PKC-alpha and -beta inhibitor and an inducible nitric oxide synthase (NOS) inhibitor decreased the induction of COX-2 by HMCM and VEGF
Leung et al., Int J Oncol 2003 (Carcinoma...) : Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma
Yoshida et al., Lab Invest 2003 (Carcinoma, Lewis Lung...) : In this model, VEGF expression was down-regulated by selective COX-2 inhibition with NS-398
Wang et al., Biochem Biophys Res Commun 2004 : Thus, vHL/HIF-1alpha has a regulatory role in COX-2 mediated VEGF production in hypoxic stellate cells in injured liver
Spinella et al., Clin Cancer Res 2004 (MAP Kinase Signaling System...) : COX-2 inhibitors and, in part, COX-1 inhibitor blocked ET-1 induced PGE ( 2 ) and vascular endothelial growth factor release, indicating that both enzymes participate in PGE ( 2 ) production to a different extent
Kyzas et al., Mod Pathol 2005 (Carcinoma, Squamous Cell...) : Our results suggest that a lymphangiogenic pathway, in which COX-2 overexpression stimulates vascular endothelial growth factor-C upregulation, probably exists in head and neck squamous cell carcinoma
Shin et al., Carcinogenesis 2004 (Adenocarcinoma...) : Furthermore, the stimulatory action of nicotine on cancer cell growth and angiogenic factor VEGF production was suppressed by inhibitors of MEK ( U0126 ) and COX-2 ( SC-236 )
Calviello et al., Carcinogenesis 2004 (Colorectal Neoplasms) : Constitutive VEGF expression was augmented in cultured HT-29 cells by serum starvation and the effects of eicosapentaenoic ( EPA ) or docosahexaenoic acid ( DHA ) on VEGF, COX-2 , phosphorylated extracellular signal regulated kinase ( ERK ) -1 and -2 and hypoxia-inducible-factor 1-alpha ( HIF-1alpha ) expression and PGE ( 2 ) levels were assessed
Youn et al., Immunol Lett 2005 (Arthritis, Rheumatoid...) : New cyclooxygenase-2 inhibitor DFU regulates vascular endothelial growth factor expression in rheumatoid synoviocytes
Diamond et al., Fertil Steril 2005 (Tissue Adhesions) : Stimulation of aerobic metabolism by DCA or inhibition of COX-2 by NS-398 reduces VEGF expression
Eibl et al., Cancer Res 2005 (Neovascularization, Pathologic...) : The aim of the present study was to evaluate the effect of selective COX-2 inhibitors on vascular endothelial growth factor ( VEGF ) production in vitro and angiogenesis and growth of pancreatic cancer in vivo, focusing on putative differences between COX-2 negative and COX-2 positive tumors ... Selective COX-2 inhibitors had a concentration dependent effect on VEGF production in vitro
Huang et al., J Biomed Sci 2005 (Neovascularization, Pathologic...) : Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma ... These in vitro angiogenic effects on HUVECs were reduced either by blocking VEGF or NS-398, a COX-2 inhibitor
Wu et al., World J Gastroenterol 2005 (Helicobacter Infections...) : These effects appear to be mediated through a NF-kappaB and COX-2 mediated pathway, as COX-2 or NF-kappaB inhibitor significantly attenuate the invasiveness of gastric cancer cells and the expressions of MMP-9 and VEGF protein
Kimba et al., Oncol Res 2005 (Anoxia...) : Mutant IkappaBalpha suppresses hypoxia induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells
Cianchi et al., Clin Cancer Res 2005 (Colorectal Neoplasms) : The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer
Imada et al., Int J Mol Med 2006 (Breast Neoplasms...) : COX-2 induces vascular endothelial growth factor ( VEGF ) and basic fibroblast growth factor (bFGF) and is thus involved in neovascularization
Soma et al., Int J Cancer 2006 (Disease Progression...) : In vitro, CDCA induced the production of PGE2 and VEGF in dose- and time dependent manners, and these effects were attenuated by a selective COX-2 inhibitor, mitogen activated protein kinases inhibitor, or epidermal growth factor receptor inhibitor ... CDCA induced COX-2 in the cell lysate increased the secretion of VEGF into the culture medium
Tamura et al., Vascul Pharmacol 2006 : VEGF induced cyclooxygenase (COX) -2 mRNA expression in HUVECs and increased the PGE2 concentration in the medium
Murphy et al., Circ Res 2006 (Ischemia) : The function of sokotrasterol sulfate was dependent on cyclooxygenase-2 activity and vascular endothelial growth factor induction , as inhibition of either cyclooxygenase-2 or vascular endothelial growth factor blocked angiogenesis
Ueno et al., Biomed Pharmacother 2006 (Breast Neoplasms) : Further studies are necessary to elucidate how COX-2 inhibitors regulate production of VEGF in different cells and different tissues in cancer patients
Li et al., Int J Gynecol Cancer 2006 (Endometrial Neoplasms...) : The present findings suggest that overexpression of COX-2 may induce the expression of VEGF , increase angiogenesis, and enhance tumor growth
Güven et al., J Endod 2007 : Recent data from the medical literature indicates that cyclooxygenase-2 (COX-2) plays a key role in the production of vascular endothelial growth factor ( VEGF ), a glycoprotein that has the ability to increase the permeability of blood vessels and to induce angiogenesis
Spinella et al., Cancer Res 2007 (Melanoma...) : Moreover, COX-1/COX-2 inhibitors block ET-induced PGE ( 2 ) and VEGF secretion, matrix metalloproteinase ( MMP ) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties
Boosani et al., Blood 2007 (Neoplasms...) : We show that binding of alpha3 ( IV ) NC1 to alpha3beta1 integrin leads to inhibition of COX-2 mediated pro-angiogenic factors, vascular endothelial growth factor , and basic fibroblast growth factor by regulating IkappaBalpha/NFkappaB axis, and is independent of alphaVbeta3 integrin
Gollogly et al., J Surg Res 2007 : In endothelial cells, binding of vascular endothelial growth factor ( VEGF ) to VEGF receptor 2 leads to the activation of the serine/threonine phosphatase calcineurin, dephosphorylation of the nuclear factor of activated T-cells ( NF-AT ) transcription factors, translocation of NF-AT to the nucleus, and expression of angiogenesis related genes such as Cox-2
Oshima et al., Exp Anim 2007 : Moreover, expression of vascular endothelial growth factor ( VEGF ) is also induced in the heart in a COX-2 dependent manner
Lei et al., Zhonghua Yi Xue Za Zhi 2007 (Neoplasms, Experimental...) : COX-2 can stimulate VEGF and enhance the proliferation of endothelial cells by upregulating Id1, and blocking this pathway may be helpful to the tumor therapeutics, so COX-2 and Id1 can be exploited as therapeutic targets of gastric cancer
Zhu et al., BMC cancer 2008 (Carcinoma, Non-Small-Cell Lung...) : Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells ... We speculated that inhibition of COX-2 activity might reduce expression of the pro-angiogenic factors vascular endothelial growth factor ( VEGF ) and interleukin-8 (IL-8) in lung cancer cells ... However, VEGF production is, at least partly, COX-2 dependent in NSCLC cells expressing COX-2
Brant et al., Toxicological sciences : an official journal of the Society of Toxicology 2009 : Consistent with our previous findings that Ni and MALP-2 stimulates the induction of CXCL8 via a COX-2 mediated pathway, CXCL1, CXCL5, and VEGF release were also regulated by COX-2
Tjiu et al., J Invest Dermatol 2009 (Carcinoma, Basal Cell...) : Macrophages also induced COX-2 dependent secretion of basic fibroblast growth factor and vascular endothelial growth factor-A , and increased angiogenesis in BCC cells
Valcárcel et al., Journal of translational medicine 2008 (Colorectal Neoplasms...) : More importantly, spheroid derived CT26 cells increased lymphocyte function associated antigen ( LFA ) -1-expressing cell fraction by 3-fold ; and soluble intercellular adhesion molecule (ICAM)-1, given to spheroid cultured CT26 cells, further increased VEGF secretion by 90 %, via cyclooxygenase (COX)-2 dependent mechanism
Hu et al., Proc Natl Acad Sci U S A 2009 (Breast Neoplasms...) : Up-regulation of COX-2 in DCIS xenografts resulted in increased VEGF and MMP14 expression, which may contribute to the larger weight and invasive histology of COX-2 expressing tumors
Liu et al., Anat Rec (Hoboken) 2009 (Adenocarcinoma...) : Here, the effects of COX-2 inhibitor on vascular endothelial growth factor-C ( VEGF-C ) expression, lymphangiogenesis and lymph node metastasis were investigated
Doyle et al., Domest Anim Endocrinol 2010 : The PTGS2 response to 1 ng/mL VEGF was similar to that induced by treatment with luteinizing hormone ( LH )
Chien et al., Carcinogenesis 2009 (MAP Kinase Signaling System...) : However, VEGF-C induced COX-2 upregulation was effectively abolished by overexpression of dominant negative c-Jun N-terminal kinase (JNK) or treatment with the JNK inhibitor, SP 600125
Valamanesh et al., Molecular vision 2009 : Experiments performed on primary RPE cells showed that TA downregulates the basal expression of COX-2 and VEGF and inhibits the outer segments ( OS ) -dependent COX-2 induction but not the OS-dependent VEGF induction
Scoditti et al., Cardiovasc Res 2010 : As both protein kinase C (PKC)alpha and beta are involved in VEGF induced COX-2 expression and CREB activation, we investigated which isoform ( s ) of PKC was affected by RSG ... VEGF induces CREB mediated COX-2 expression through a PKCalpha dependent pathway in human endothelium ... The anti-angiogenic effect of PPARgamma agonists is due, at least in part, to an interference with the VEGF stimulated PKCalpha mediated activation of CREB and the related expression of COX-2
Toomey et al., Pancreas 2010 (Neovascularization, Pathologic...) : This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in angiogenesis and VEGF regulation ... Cyclooxygenase 2 does not regulate VEGF in pancreatic cancer, and celecoxib upregulates VEGF in pancreatic cancer
Park et al., Head Neck 2010 (Carcinoma, Squamous Cell...) : The majority of the anticancer effects of COX-2-inhibitors in HNSCC cells seem to result from COX-2 independent action, suggesting that COX-1 and COX-2 may contribute to VEGF synthesis in cancer cells through a prostaglandin dependent mechanism
Yao et al., J Exp Clin Cancer Res 2011 (Neoplasms, Experimental...) : The results of RT-PCR and western blot showed that down-regulation of COX-2 might inhibit VEGF , Flt-1, Flk-1/KDR, angiopoietin-1, tie-2, MMP2 and OPN
Kim et al., Korean journal of urology 2011 : Chronic inflammation in BPH causes an overexpression of COX-2 , which induces the increased expression of Bcl-2 and VEGF
Zhao et al., Mol Cell Biochem 2012 (MAP Kinase Signaling System) : VEGF production in PDGF stimulated HSCs is dependent on the overexpression of COX-2 protein via the phospho-p42/44 MAP kinase activation, based on PD98059 inhibition
Valcárcel et al., Journal of translational medicine 2011 (Bone Marrow Neoplasms...) : Recombinant TNFa induced B16M production of VEGF via COX-2 dependent mechanism ... We demonstrate the contribution of VEGF induced tumor COX-2 to the regulation of adhesion- and proliferation stimulating effects of TNFa, from endotoxin activated bone marrow stromal cells, on VLA-4 expressing melanoma cells
Cintra et al., Clinics (Sao Paulo) 2011 (Bone Neoplasms...) : Angiogenesis can be quantified by measuring the expression of vascular endothelial growth factor and CD34, and cyclooxygenase-2 can induce angiogenesis by stimulating the production of proangiogenic factors
Ji et al., International journal of medical sciences 2012 (Neovascularization, Pathologic...) : Our results suggest that expression of COX-2 and VEGF may promote angiogenesis of thyroid carcinoma, its infiltration, and metastasis
Garufi et al., PloS one 2012 : THESE FINDINGS SHOW THAT : 1 ) HIPK2 knockdown induced COX-2 upregulation, mostly depending on HIF-1 activity ; 2 ) zinc treatment downregulated HIF-1 induced COX-2 and inhibited PGE ( 2 ) /VEGF production ; and 3 ) zinc treatment of HIPK2 depleted cells restored DCs maturation
Salimi et al., J Environ Pathol Toxicol Oncol 2012 (Carcinoma, Squamous Cell...) : This study was designed to evaluate the action of nicotine in the oral cancer cell and to further examine whether COX-2 is responsible for expression of tumor associated angiogenic vascular endothelial growth factor ( VEGF ) in vitro
Voloshin et al., Anesteziol Reanimatol 2013 (Pain, Postoperative) : It is assumed that the COX-2 inhibitors may inhibit vascular endothelial growth factor of the tumor and so inhibit angiogenesis of solitary tumors and metastases, without affecting the normal endothelium