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AHSA1 — NOX1
Text-mined interactions from Literome
Benhar et al., Mol Cell Biol 2001
:
JNK/p38 activation is
inhibited by antioxidants and in particular by inhibitors of the mitochondrial respiratory chain and
NADPH oxidase
Cooper et al., Free Radic Biol Med 2009
(Cell Transformation, Neoplastic...) :
Furthermore, arsenite induced, but not UVA induced,
p38 activation and HO-1 expression were
dependent upon
NADPH oxidase activity
Quiroga et al., Growth Factors 2009
(Liver Neoplasms...) :
p38 MAPK induced
activation of
NADPH oxidase is accomplished by a two-step pathway : first, ROS independent and second ROS- and TGF-beta(1) dependent
Markvicheva et al., Bioorg Khim 2010
(MAP Kinase Signaling System) :
The activation of Erkl/2 is dependent, and the activation of
p38 is not
dependent , on the activity of
NADPH oxidase
Hu et al., Journal of neuroinflammation 2011
:
In addition, microglial
p38 and p44/42 MAPKs were found to be phosphorylated in response to viral infection and this activation was also
blocked by inhibitors of
NADPH oxidase
Zhao et al., Am J Physiol Heart Circ Physiol 2012
(Disease Models, Animal...) :
Gel kinase assay was employed to detect the
effect of
p38 on
Nox2 phosphorylation
Kodama et al., Genes Cells 2013
:
Furthermore,
Nox1 and Nox4 siRNAs
inhibited both Ras induced DNA damage response and
p38MAPK activation, whereas overexpression of Nox1 and Nox4 alone was able to induce senescence