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IL6 — PTHLH
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
De Miguel et al., J Am Soc Nephrol 1999
:
Parathyroid hormone related protein ( 107-139 )
stimulates interleukin-6 expression in human osteoblastic cells ... PTH ( 1-34 ) and
PTHrP ( 1-34 ) rapidly
induce interleukin-6 (IL-6) expression by osteoblasts ... The aim of the present study was to assess the
effects of
PTHrP ( 107-139 ) on
IL-6 gene expression and secretion by osteoblastic cells from human trabecular bone ( hOB ) ... Both
PTHrP ( 1-34 ) and PTHrP ( 107-139 ), but not PTHrP ( 38-64 ),
stimulated IL-6 secretion to the hOB cell conditioned medium at 24 h, dose dependently ... These results indicate that C-terminal
PTHrP , like its N-terminal domain,
induces IL-6 production by human osteoblastic cells
Radeff et al., Cell Signal 2004
(Bone Resorption) :
PTH 1-34, PTH 3-34,
PTHrP and PTH 1-31
stimulated PKCalpha translocation and
IL-6 promoter activity
Chen et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Luciferase promoter assays revealed that regulation of IL-6 involved the cAMP dependent protein kinase A and MAPK pathways with a potential minor role of the protein kinase C pathway, and a promoter region containing an activator protein-1 site was necessary for
PTHrP induced
IL-6 gene transcription ... Phosphorylation of the transcription factor CREB was also necessary but not sufficient for
PTHrP mediated
IL-6 promoter activity ... These data indicate that inactivation of the MAPK pathway shows differential regulation of PTHrP stimulated activator protein-1 members, blocks
PTHrP stimulated
IL-6 , and synergistically down-regulates certain osteoblastic markers associated with differentiation
Guillén et al., Calcif Tissue Int 2004
(Bone Neoplasms...) :
PD098059, a mitogen activated protein kinase ( MAPK ) kinase inhibitor, at 10 microM, and two inhibitors of protein prenylation and thus Ras activation, simvastatin ( 1 microM ) and a farnesyltransferase ( FTase ) inhibitor ( 100 nM ), but not the phosphatidylinositol 3-kinase inhibitor wortmannin, blocked the
IL-6/IL-6sR induced
PTHrP expression in these cells
Tenta et al., Horm Metab Res 2005
(Prostatic Neoplasms) :
Consequently, we have investigated whether IGF-1, TGF-beta1, bFGF,
IL-6 , zoledronic acid and/or dexamethasone
affect the expression of the
PTHrP and type I PTH/PTHrP receptor ( PTH.1R ) in PC-3 prostate cancer cells using relative quantitative PCR and real-time PCR ( expression at mRNA level ) and immunocytochemical and immunofluorescence analysis ( expression at protein level )
Tenta et al., Anticancer Res 2006
(Bone Neoplasms...) :
Whether IGF-1, TGF beta 1, bFGF,
IL-6 and zoledronic acid
affect the expressions of
PTHrP and PTH.1R in MG-63 osteoblast-like osteosarcoma cells was investigated in this study ... Our data showed that primarily IGF-1, TGF beta 1 and
IL-6 ( up to 25 ng/ml for 48 h )
increased PTHrP mRNA expression and modified its perinuclear localization, while zoledronic acid ( up to 100 microM for 48 h ) inhibited cell proliferation and suppressed PTHrP expression in the MG-63 osteosarcoma cells
Saito et al., Cancer Sci 2007
(Cachexia...) :
These results demonstrate that production of PTHrP and
IL-6 largely depends on the microenvironments in which tumors are developed or metastasized and that up-regulation of COX-2 in a necrobiotic environment
leads to
PTHrP production, thereby causing cachectic syndromes
Ikeda et al., Endocrinology 1993
(Deltaretrovirus Infections...) :
The secretion of
PTHRP , as determined by both a newly established immunoradiometric assay using recombinant human PTHRP ( 1-87 ) as the standard and an RIA using an antibody against PTHRP ( 109-141 ), was
increased by IL-2 but not by IL-1, IL-3, IL-4, or
IL-6
Casey et al., J Clin Endocrinol Metab 1993
:
17 beta-Estradiol ( E2 ),
interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha), endothelin-1 (ET-1), transforming growth factor-beta 1 ( TGF beta 1 ), and serum
stimulated PTH-rP production ( evaluated by immunoassay of PTH-rP in the culture medium ) by these cells