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LPA — SETD2

Text-mined interactions from Literome

Lee et al., Clin Cancer Res 2006 (Neoplasm Invasiveness...) : In the present study, we investigated whether LPA activates hypoxia inducible factor-1 (HIF-1) , a key transcriptional complex in tumor progression and metastasis, thereby increasing the expression of VEGF
Lin et al., Am J Physiol Gastrointest Liver Physiol 2010 (Adenoma...) : In vitro studies using HCT116 cells showed that LPA induced cyclin D1, c-Myc, and HIF-1a expression, which was attenuated by knockdown of LPA ( 2 )
Lee et al., J Biol Chem 2013 (Colonic Neoplasms) : We have shown previously that LPA stimulates HIF-1a expression in colon cancer cells ... To determine the mechanism of HIF-1a induction by LPA , we compared the effect of LPA on HIF-1a in several colon cancer cell lines ... LPA transcriptionally induced HIF-1a in colon cancer cells ... Silencing of KLF5 inhibited LPA induced HIF-1a induction, suggesting that KLF5 is an upstream regulator of HIF-1a