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HMGB1 — NOX1
Text-mined interactions from Literome
Fan et al., J Immunol 2007
(Reperfusion Injury...) :
Hemorrhagic shock induces
NAD ( P ) H oxidase activation in neutrophils : role of
HMGB1-TLR4 signaling ... Thus, PMN
NAD ( P ) H oxidase activation,
induced by HS/R and as mediated by
HMGB1/TLR4 signaling, is an important mechanism responsible for PMN mediated inflammation and organ injury after hemorrhage
Li et al., Am J Physiol Regul Integr Comp Physiol 2009
(Acute Lung Injury...) :
Furthermore, the results demonstrate that
HMGB1 induces activation of
NAD ( P ) H oxidase and expression of ICAM-1 in the lung, and MLVECs sequentially depend on TLR4 in the early phase and on TLR2 in the late phase following HS
Gao et al., J Neurosci 2011
(Inflammation...) :
Mechanistic studies indicated that
HMGB1 ( high-mobility group box 1 ), released from inflamed microglia and/or degenerating neurons, bound to microglial Mac1 ( macrophage antigen complex 1 ) and
activated nuclear factor-?B pathway and
NADPH oxidase to stimulate production of multiple inflammatory and neurotoxic factors