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IFNG — IFNGR1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IFNGR1 → IFNG (increases) Igarashi et al., J Biol Chem 1994
  Evidence: In this report, we show that binding of IFN-gamma to HeLa cells initiated a series of events that resulted in the extremely rapid (15 s) tyrosine phosphorylation of not only Jak1, Jak2, and p91 but also the IFN-gamma R.
• BioCarta chaperones modulate interferon signaling pathway: IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2 complex (IFNG-IFNGR1-JAK2) → TID1 (DNAJA3) (modification, collaborate)
• BioCarta chaperones modulate interferon signaling pathway: IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2 complex (IFNG-IFNGR1-JAK2) → IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3) (modification, collaborate)
  
• BioCarta chaperones modulate interferon signaling pathway: TID1 (DNAJA3) → IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3) (modification, collaborate)
  
• BioCarta chaperones modulate interferon signaling pathway: IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1/HSP70 complex (IFNGR1-JAK2-DNAJA3-HSPA1A) → IFN-gamma (IFNG) (modification, collaborate)
• BioCarta chaperones modulate interferon signaling pathway: IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1/HSP70 complex (IFNGR1-JAK2-DNAJA3-HSPA1A) → IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3) (modification, collaborate)
  
• BioCarta chaperones modulate interferon signaling pathway: IFN-gamma (IFNG) → IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3) (modification, collaborate)
  
• BioCarta chaperones modulate interferon signaling pathway: HSP70 (HSPA1A) → IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3) (modification, collaborate)
  
• BioCarta ifn gamma signaling pathway: IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK2 complex (JAK1-JAK2-IFNGR1) → IFN-gamma (IFNG) (modification, collaborate)
• BioCarta ifn gamma signaling pathway: IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK2 complex (JAK1-JAK2-IFNGR1) → IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK1/JAK2/JAK2 complex (JAK1-JAK2-IFNGR1-IFNG) (modification, collaborate)
  
• BioCarta ifn gamma signaling pathway: IFN-gamma (IFNG) → IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK1/JAK2/JAK2 complex (JAK1-JAK2-IFNGR1-IFNG) (modification, collaborate)
  
• KEGG Osteoclast differentiation: IFNG → IFNGR1/IFNGR2 (protein-protein, activation)
• KEGG Natural killer cell mediated cytotoxicity: IFNG → IFNGR1/IFNGR2 (protein-protein, activation)
• KEGG Natural killer cell mediated cytotoxicity: IFNA1/IFNA10/IFNA13/IFNA14/IFNA16/IFNA17/IFNA2/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA8/IFNB1/IFNG → IFNAR1/IFNAR2/IFNGR1/IFNGR2 (protein-protein, activation)
  
• KEGG Natural killer cell mediated cytotoxicity: IFNG → IFNAR1/IFNAR2/IFNGR1/IFNGR2 (protein-protein, activation)
  
• KEGG Leishmaniasis: IFNG → Complex of IFNGR1-IFNGR2 (protein-protein, binding/association)
• KEGG Chagas disease (American trypanosomiasis): IFNG → IFNGR1/IFNGR2 (protein-protein, activation)
• KEGG Chagas disease (American trypanosomiasis): IFNG → IFNGR1/IFNGR2 (protein-protein, activation)
• KEGG Toxoplasmosis: IFNG → IFNGR1/IFNGR2 (protein-protein, binding/association)
• KEGG Tuberculosis: IFNG → IFNGR1 (protein-protein, activation)
• KEGG Measles: IFNG → IFNGR1/IFNGR2 (protein-protein, activation)
• KEGG Influenza A: IFNG → IFNGR1/IFNGR2 (protein-protein, binding/association)
• KEGG Cytokine-cytokine receptor interaction: IFNG → Complex of IFNGR1-IFNGR2 (protein-protein, activation)
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → MEKK1 (MAP3K1) (modification, activates) Roy et al., Proc Natl Acad Sci U S A 2002
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → SHP2 (PTPN11) (translocation, activates) Wu et al., J Biol Chem 2002
  Evidence: assay
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2) (modification, collaborate)
  You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → IFN-gamma (dimer) complex (IFNG) (modification, collaborate)
  You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2) → IFN-gamma (dimer) complex (IFNG) (modification, collaborate)
  You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TCPTP complex (IFNGR1-JAK1-JAK2-IFNG-PTPN2) (modification, collaborate)
  Simoncic et al., Curr Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → TCPTP p45 (PTPN2) (modification, collaborate) Simoncic et al., Curr Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TCPTP complex (IFNGR1-JAK1-JAK2-IFNG-PTPN2) → TCPTP p45 (PTPN2) (modification, collaborate) Simoncic et al., Curr Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → CBL (CBL) (modification, activates) Alsayed et al., J Immunol 2000
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → CaM/Ca2+/CAMKII complex (CALM2-CAMK2A_CAMK2B_CAMK2D_CAMK2G) (modification, activates)
  Nair et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → Ca2+/CaM complex (CALM2) (modification, activates) Nair et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → CaMKII family (CAMK2A/CAMK2B/CAMK2D/CAMK2G) (modification, activates)
  Nair et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → None (modification, activates) Nair et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → SHP2 (PTPN11) (translocation, activates) Wu et al., J Biol Chem 2002
  Evidence: assay
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → STAT1 (STAT1) (modification, activates) Shuai et al., Science 1992*, Igarashi et al., J Biol Chem 1994, Shuai et al., Science 1993, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Nguyen et al., J Biol Chem 2001, Deb et al., J Immunol 2003
  Evidence: mutant phenotype
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → SOCS1 (SOCS1) (modification, collaborate) Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1) (modification, collaborate)
  Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: SOCS1 (SOCS1) → IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1) (modification, collaborate)
  Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → MAP3K11 (MAP3K11) (modification, activates) Roy et al., J Biol Chem 2005
  Evidence: mutant phenotype
• Reactome Reaction: IFNGR1 → IFNG (indirect_complex) Thiel et al., Structure 2000*, Krause et al., Mol Cell Proteomics 2002, Fountoulakis et al., Eur J Biochem 1992*, Argetsinger et al., Mol Cell Biol 2004, Matsuda et al., Biochem Biophys Res Commun 2004, Costa-Pereira et al., J Immunol 2005, Krause et al., Cell Res 2006*, Argetsinger et al., Mol Endocrinol 2010, Igarashi et al., J Biol Chem 1994, Sakatsume et al., J Biol Chem 1995*, Walter et al., Nature 1995*, Kotenko et al., J Biol Chem 1995*, Kaplan et al., J Biol Chem 1996*, Briscoe et al., EMBO J 1996, Feng et al., Mol Cell Biol 1997
• Reactome Reaction: IFNGR1 → IFNG (reaction) Thiel et al., Structure 2000*, Aaronson et al., Science 2002, Krause et al., Mol Cell Proteomics 2002, Fountoulakis et al., Eur J Biochem 1992*, Argetsinger et al., Mol Cell Biol 2004, Matsuda et al., Biochem Biophys Res Commun 2004, Costa-Pereira et al., J Immunol 2005, Krause et al., Cell Res 2006*, Argetsinger et al., Mol Endocrinol 2010, Igarashi et al., J Biol Chem 1994, Sakatsume et al., J Biol Chem 1995*, Walter et al., Nature 1995*, Quelle et al., J Biol Chem 1995, Kotenko et al., J Biol Chem 1995*, Shuai et al., Science 1993, Kaplan et al., J Biol Chem 1996*, Briscoe et al., EMBO J 1996, Feng et al., Mol Cell Biol 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IFNGR1 — IFNG Thiel et al., Structure 2000*
• IRef Bind Interaction: IFNG — IFNGR1 Randal et al., Structure 2001*, Randal et al., Protein Sci 1998*
• IRef Bind_translation Interaction: IFNGR1 — IFNG (x-ray crystallography) Thiel et al., Structure 2000*
• IRef Bind_translation Interaction: IFNGR1 — IFNG (x-ray crystallography) Randal et al., Protein Sci 1998*
• IRef Biogrid Interaction: IFNG — IFNGR1 (association, x-ray crystallography) Thiel et al., Structure 2000*
• IRef Biogrid Interaction: IFNG — IFNGR1 (direct interaction, pull down) Kotenko et al., J Biol Chem 1995*
• IRef Dip Interaction: IFNG — IFNGR1 (direct interaction, x-ray crystallography) Landar et al., J Mol Biol 2000*
• IRef Dip Interaction: IFNG — IFNGR1 (direct interaction, x-ray crystallography) Walter et al., Nature 1995*
• IRef Hprd Interaction: IFNG — IFNGR1 (in vitro) Thiel et al., Structure 2000*, Randal et al., Structure 2001*, Subramaniam et al., J Immunol 2002*
• IRef Hprd Interaction: IFNG — IFNGR1 (in vivo) Thiel et al., Structure 2000*, Randal et al., Structure 2001*, Subramaniam et al., J Immunol 2002*
• IRef Innatedb Interaction: IFNG — IFNGR1 (unknown, -) Thiel et al., Structure 2000*
• IRef Innatedb Interaction: IFNG — IFNGR1 (unknown, -) Kotenko et al., J Biol Chem 1995*
• IRef Intact Interaction: IFNG — IFNGR1 (direct interaction, x-ray crystallography) Randal et al., Structure 2001*
• IRef Ophid Interaction: IFNG — IFNGR1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Qing et al., J Biol Chem 2005 : Mutation of Tyr ( 441 ) also blocked the ability of SOCS-1 to bind to IFNGR1 and JAK2 in response to IFNgamma and the normal down-regulation of STAT1 activation and antiviral activity
Sun et al., Nat Immunol 2006 : IFN-gamma stimulation triggered a physical association between the IFN-gammaR1 and MyD88
Wood et al., Trends Immunol 2006 : This early production of IFNgamma by induced Treg cells during an immune response can directly inhibit the activation and proliferation of IFNgammaR1- and IFNgammaR2 bearing T cells
Takaki et al., Genes Cells 2006 : Thus, multiple mechanisms are present for the TGF-beta1 mediated reduction of iNOS production, and we propose a novel mechanism for regulating inflammatory cytokine by an anti-inflammatory cytokine, TGF-beta1 ; i.e. suppression of IFN-gamma induced STAT1 activation by an association of the IFNGR1 with the TGF-betaRI
Sun et al., J Interferon Cytokine Res 2007 : Expression of IRF-1 was induced and expression of active caspase-3 was promoted by IFN-gamma treatment, but IFN-gamma did not affect the expression of IFNGR and p53
Bustamante et al., Curr Opin Immunol 2008 (Genetic Diseases, Inborn...) : Mutations in IFNGR1 and IFNGR2 impair IFN-gamma responses and confer a predisposition to mycobacterial diseases
Wang et al., Cancer Res 2008 (Esophageal Neoplasms) : Taken together, our results disclosed a new IRF-2 mediated inhibitory mechanism for IFN-gamma induced pathway in esophageal cancer cells : IFN-gamma induced IRF-2 up-regulation, then up-regulated IRF-2 decreased endogenous IFNGR1 level, and finally, the loss of IFNGR1 turned to enhance the resistance of esophageal cancer cells to IFN-gamma
Ahmad et al., Osteoarthritis Cartilage 2009 (Osteoarthritis) : Therefore, IFN-gammaR1 modulation and weakened endogenous IFN-gamma response may be important mechanisms in OA pathogenesis and cartilage degradation