Gene interactions and pathways from curated databases and text-mining

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IL1RAP — IL2

Text-mined interactions from Literome

Ali et al., Proc Natl Acad Sci U S A 2007 : IL-33 activates IL-1 receptor associated kinase-1, cJun-N-terminal kinase, and the NF-kappaB pathway in an IL-1RAcP dependent manner and results in IL-2 release
Korherr et al., Eur J Immunol 1997 : A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling
Wesche et al., J Biol Chem 1997 : The expression of IL-1RAcP in EL-4 D6/76 was sufficient to restore IL-1 induced activation of interleukin-1 receptor associated kinase and of stress activated protein kinases, translocation of the transcription factors NFkappaB and IL-1 NF to the nucleus, and induction of IL-2 mRNA synthesis