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IL2 — RUNX1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wong et al., J Biol Chem 2011
:
Down-regulation of
Runx1 expression by TCR signal involves an autoregulatory mechanism and
contributes to
IL-2 production ... Through the use of Runx1 overexpressing cells from transgenic mice, we demonstrate that interference with TCR mediated
Runx1 down-regulation
inhibits IL-2 production and proliferation in activated CD4+ T cells ... In summary, we propose that high levels of Runx1 in resting CD4+ T cells functions negatively in the regulation of IL-2 transcription, and that TCR activation mediated down-regulation of
Runx1 involves negative auto-regulation of the distal Runx1 promoter and
contributes to
IL-2 production
Presnell et al., J Immunol 2012
:
IL-2- and IL-15 stimulated human NK cell lines
increased 2DL4 promoter activity, which required functional
Runx , CRE, and Ets sites