Tataranni et al., Am J Transplant 2011
(Hypophosphatemia...) :
Rapamycin treatment of an immortalized proximal tubular cell line induced the expression of Klotho , the phosphorylation of AKT in Ser473, downstream target of mTORC2 and the expression of RICTOR, mTORC2 main component ... AKT inhibition reduced the rapamycin induced expression of Klotho Shu et al., Cellular oncology (Dordrecht) 2013
(Carcinoma, Hepatocellular...) :
Exogenous klotho gene expression also down-regulated the phosphorylation levels of the IGF-1 receptor, and the downstream Akt , ERK, and p70S6K proteins