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EPHB2 — GCG

Text-mined interactions from Literome

Jiang et al., Proc Natl Acad Sci U S A 2001 : In addition, chelation of intracellular calcium reduced glucagon mediated ERK1/2 activation ... In transient transfection experiments, glucagon receptor mutants that bound glucagon but failed to increase intracellular cAMP and calcium concentrations showed no glucagon stimulated ERK1/2 phosphorylation ... We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by PKA and that an increase in intracellular calcium concentration is required for maximal ERK activation
Dalle et al., J Biol Chem 2004 : Chelation of intracellular calcium ( intracellular [ Ca ( 2+ ) ] ) reduced glucagon mediated ERK1/2 activation ... We conclude that glucagon induced ERK1/2 activation is mediated by PKA and that an increase in [ Ca ( 2+ ) ] ( i ) is required for maximal ERK activation