Stockhausen et al., Exp Cell Res 2005
(Neuroblastoma) :
The up-regulation of Hes-1 occurred both at the transcriptional and protein levels and by use of EGFR and MEK inhibitors we could show that the Hes-1 response was dependent on activation of the MAP kinase ERK Wang et al., Neurosci Lett 2009
:
Cell-cycle regulators such as cyclin dependent kinase 2 (Cdk2), Cyclin D1 and Hes1 mediated the effect of Erk on NSCs proliferation and differentiation