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BIRC3 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Erl et al., Circ Res 1999
:
Transfer of IkappaBalpha reduced human IAP-1 mRNA levels, which suggested that
IAP-1 is transcriptionally
regulated by
NF-kappaB
Vega et al., Adv Anat Pathol 2001
(Lymphoma, B-Cell, Marginal Zone...) :
Recent work suggests that
API2-MALT1 and BCL-10-MALT1 may
activate NF-kB and a common downstream signaling pathway
Schoemaker et al., J Hepatol 2002
(Hepatitis) :
cIAP2 is induced by cytokines in an
NF-kappaB dependent manner and overexpression of cIAP2 inhibits apoptosis
Uzzo et al., Clin Cancer Res 2002
(Prostatic Neoplasms) :
In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of
nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate cancer cells,
reduce expression of NF-kappa B-controlled antiapoptotic protein
c-IAP2 , and activate c-Jun NH ( 2 ) -terminal kinases
Wen et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Consistent with this, we found that TL1A significantly increased the production of
c-IAP2 , a known NF-kappaB dependent anti-apoptotic protein, and that the
NF-kappaB inhibitor or cycloheximide
prevented its synthesis
Wang et al., J Biol Chem 2003
(Colonic Neoplasms) :
Activation of
NF-kappa B contributes to
cIAP-2 induction ; however, the cellular mechanisms regulating cIAP-2 expression have not been entirely defined ... Moreover, overexpression of PKC delta induced
cIAP-2 promoter activity and increased
NF-kappa B transactivation , suggesting regulation of cIAP-2 expression by a PKC delta/NF-kappa B pathway
Nawata et al., Oncogene 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Expression of MEKK1km also reduced
NF-kappaB activation, and
inhibited antiapoptotic c-IAP1 and
c-IAP2 mRNA expression in response to the genotoxin
Yanai et al., J Infect Dis 2003
(Stomach Neoplasms) :
Super-repressor IkappaBalpha or
NF-kappaB inhibitor
reduced c-IAP2 transactivation by H. pylori, and exogenous expression of c-IAP2 inhibited apoptosis seen with H. pylori
Hübinger et al., Exp Hematol 2004
(Lymphoma, Large B-Cell, Diffuse) :
Furthermore, we showed that CD30 regulated expression of cIAP1 and
cIAP2 was
mediated by
NFkappaB
Hosokawa et al., Int J Hematol 2004
(Lymphoma, B-Cell, Marginal Zone) :
BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation can be assumed to be able to contribute to antiapoptosis, probably through NF-kappaB mediated up-regulation of several apoptotic inhibitor genes
Ho et al., Blood 2005
(Lymphoma, B-Cell...) :
API2-MALT1 and exogenous MALT1
increased constitutive
NF-kappa B activity and enhanced I kappa B kinase (IKK) activation induced by CD40 stimulation
Fan et al., Oncogene 2005
:
HGF/SF induced the expression of several known NF-kappaB target genes ( cIAP-1 ( cellular inhibitor of apoptosis-1 ),
cIAP-2 , and TRAF-2 ( TNF receptor associated factor-2 ) ) in an
NF-kappaB dependent manner ; HGF/SF blocked the inhibition of expression of these genes by ADR
Hosokawa et al., Apoptosis 2005
(Lymphoma, B-Cell, Marginal Zone...) :
This stability of
API2-MALT1 may thus
result in inappropriate
nuclear factor (NF)-kappaB activation, thereby contributing to the pathogenesis of MALT lymphoma ... Furthermore, BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation may contribute to anti-apoptotic action probably through NF-kappaB mediated upregulation of apoptotic inhibitor genes
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
Furthermore, BCL10 and
cIAP2-MALT1 synergistically
activate NF-kappaB
Zhou et al., Br J Haematol 2006
(Lymphoma, B-Cell, Marginal Zone...) :
t ( 11 ; 18 ) ( q21 ; q21 ) occurs specifically in mucosa associated lymphoid tissue ( MALT ) lymphoma and the translocation generates a functional
API2-MALT1 fusion product that
activates nuclear factor (NF)kappaB
Nakagawa et al., Leukemia 2006
(Lymphoma, B-Cell, Marginal Zone) :
We recently demonstrated that
API2-MALT1 can
induce transactivation of the API2 gene through
NF-kappaB activation, thus highlighting a positive feedback-loop mechanism of self-activation by upregulating its own expression in t ( 11 ; 18 ) MALT lymphomas
Hu et al., Cell cycle (Georgetown, Tex.) 2006
:
Furthermore,
cIAP2-MALT1 and Bcl10 synergistically
activate NF-kappaB
Jin et al., Biochem J 2006
:
cIAP2 ( cellular inhibitor of apoptosis protein 2 ) is
induced by
NF-kappaB ( nuclear factor kappaB ) when cells need to respond quickly to different apoptotic stimuli ... Cell cycle dependent G2/M-phase-specific
cIAP2 expression is
enhanced by
NF-kappaB activation, and selective down-regulation of cIAP2 causes cells blocked in mitosis with nocodazole to become susceptible to apoptosis, indicating that the G2/M-phase-specific expression of cIAP2 contributes to the survival of mitotically arrested cells
Noels et al., J Biol Chem 2007
(Lymphoma, B-Cell, Marginal Zone...) :
Finally, binding of TRAF2 to BIR1 contributed to
NF-kappaB activation by
API2.MALT1 , although additional mechanisms involving BIR1 mediated raft association are also important
Lucas et al., Oncogene 2007
:
A dual role for the API2 moiety in
API2-MALT1 dependent
NF-kappaB activation : heterotypic oligomerization and TRAF2 recruitment ... Thus, API2 moiety mediated heterotypic oligomerization and TRAF2 binding both contribute to maximal
API2-MALT1 dependent
NF-kappaB stimulation
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular
inhibitor of apoptosis protein-1 , cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Ricci et al., Cancer Cell 2007
:
TRAIL
induced expression of antiapoptotic Mcl-1 and
cIAP2 through activation of
NF-kappaB
Kim et al., Cancer Lett 2008
:
In addition, treatment of PTX-2 down-regulated
NF-kappaB dependent gene expression, Cox-2,
IAP-1 , IAP-2 and XIAP, at the transcriptional and translational level
Varfolomeev et al., J Biol Chem 2008
:
Here we investigate the
role of c-IAP1 and
c-IAP2 in TNFalpha stimulated activation of
NF-kappaB ... Therefore, c-IAP1 and
c-IAP2 are
required for TNFalpha stimulated RIP1 ubiquitination and
NF-kappaB activation
Mahoney et al., Proc Natl Acad Sci U S A 2008
:
Both cIAP1 and
cIAP2 regulate TNFalpha mediated
NF-kappaB activation
Garrison et al., Oncogene 2009
:
Here, we investigated the role of TRAF2 in
c-IAP2/MALT1 induced
NF-kappaB activation ... Studies of
c-IAP2/MALT1 BIR1 mutant ( E47A/R48A ) that fails to
activate NF-kappaB showed loss of TRAF2 binding, but retention of TRAF6 binding, suggesting that interaction of c-IAP2/MALT1 with TRAF6 is insufficient for NF-kappaB induction ... Comparisons of the bioactivity of intact c-IAP2/MALT1 oncoprotein and BIR1 E47A/R48A c-IAP2/MALT1 mutant that can not bind TRAF2 in a lymphoid cell line provided evidence that TRAF2 interaction is critical for
c-IAP2/MALT1 mediated increases in the
NF-kappaB activity, increased expression of endogenous NF-kappaB target genes ( c-FLIP, TRAF1 ), and resistance to apoptosis
Momeny et al., Med Oncol 2010
:
Altogether, these issues show for the first time that ATO treatment could trammel cell growth and proliferation as well as induces apoptosis in NB-4 cells through induction of transcriptional levels of p73, TP53INP1, WNK2, lipocalin 2 as well as suppression of
NF-kappaB mediated induction of BCL-X ( L ),
cIAP2 , XIAP and survivin
Kwon et al., Biochem Biophys Res Commun 2010
(Neoplasms) :
Furthermore, expression of
NF-kappaB dependent genes, FLICE-inhibitory protein (FLIP),
inhibitor of apoptosis protein 1 ( c-IAP1 ), or X-linked inhibitor of apoptosis protein ( XIAP ) was reduced in TOPK depleted cells
Lu et al., J Neurochem 2010
(Ischemia...) :
The U0126 neuroprotection appears related to
NF-kappaB regulated transcriptional control of
c-IAP2
Fingas et al., Hepatology 2010
(Bile Duct Neoplasms...) :
Because cIAP-1 and
cIAP-2 also
promote nuclear factor kappa B (NF-kappaB) activation by the canonical pathway, the effect of JP1584 on this signaling pathway was examined
Chu et al., Proc Natl Acad Sci U S A 1997
:
When overexpressed in mammalian cells,
c-IAP2 activates
NF-kappaB and suppresses TNF cytotoxicity