◀ Back to RELA

RELA — TNFSF11

Text-mined interactions from Literome

Myers et al., FEBS Lett 1999 (Calcium Signaling) : We have shown that RANK is highly expressed in mature osteoclasts and that its stimulation by RANKL results in activation of NF-kappaB and calcium signalling
Lacey et al., Am J Pathol 2000 : In contrast, OPGL enhanced both NF-kappaB and JNK kinase activation and increased the expression of c-src, but not bcl-2 and bcl-X ( L ) mRNA
Takayanagi et al., Nature 2000 (Arthritis...) : IFN-gamma induces rapid degradation of the RANK adapter protein, TRAF6 ( tumour necrosis factor receptor associated factor 6 ), which results in strong inhibition of the RANKL induced activation of the transcription factor NF-kappaB and JNK
Wei et al., Endocrinology 2001 : We report that RANK-L rapidly induces NF-kappa B activation in both authentic osteoclast precursors, namely bone marrow macrophages, and RAW 264.7 cells, a murine macrophage line also capable of RANK-L mediated osteoclastogenesis ... RANK-L activates NF-kappa B in both bone marrow macrophages and RAW 264.7 cells by serine phosphorylation of I kappa B alpha within 5 min, resulting in rapid I kappa B alpha degradation and resynthesis
Fiumara et al., Blood 2001 (Hodgkin Disease) : Previous studies reported that receptor activator of nuclear factor kappaB (NF-kappaB) ( RANK ), a member of the TNF receptor family, is expressed on DCs, and that RANK ligand (RANKL) enhances DC survival and induces them to secrete cytokines ... Soluble RANKL activated NF-kappaB and induced messenger RNA expression of interferon-gamma, interleukin-8 (IL-8), IL-13, IL-9, IL-15, and RANTES, in addition to the receptors for IL-9, IL-13, IL-15, and CCR4
Wei et al., J Biol Chem 2002 (MAP Kinase Signaling System) : We find that although pretreatment of BMMs with IL-4 does not alter M-CSF signaling, it reversibly blocks RANKL dependent activation of the NF-kappa B , JNK, p38, and ERK signals ... Consistent with this observation, the inhibitory effects of IL-4 on RANKL induced NF-kappa B and mitogen activated protein kinase activation are STAT6 dependent
Mizukami et al., Mol Cell Biol 2002 (MAP Kinase Signaling System) : Furthermore, in murine monocyte RAW 264.7 cells, dominant negative forms of TAK1 and TAB2 inhibit NF-kappaB activation induced by RANKL and endogenous TAK1 is activated in response to RANKL stimulation
Yamamoto et al., J Bone Miner Res 2002 : IKK2DN and MKK7DN overexpression in RAW cells specifically suppressed the NF-kappaB activation and JNK activation in response to RANKL , respectively, without affecting other signaling pathways
Takayanagi et al., Arthritis Res 2002 (Arthritis...) : This cytokine induces rapid degradation of the RANK ( receptor activator of nuclear factor kappaB ) adapter protein TRAF6 ( TNF-receptor associated factor 6 ), resulting in strong inhibition of the RANKL induced activation of NF-kappaB and JNK ( c-Jun N-terminal kinase )
Komarova et al., J Biol Chem 2003 : RANK ligand (RANKL) induces activation of NFkappaB , enhancing the formation, resorptive activity, and survival of osteoclasts ... RANKL induced transient translocation of NFkappaB to the nuclei, which was maximal at 15 min. or BAPTA delayed nuclear translocation of NFkappaB
Khapli et al., J Immunol 2003 : In osteoclast precursors, IL-3 prevents RANKL induced nuclear translocation of NF-kappaB by inhibiting the phosphorylation and degradation of IkappaB
Sugatani et al., J Cell Biochem 2003 : RANKL stimulation of RANK/TRAF6 signaling increases nuclear factor-kappaB (NFkappaB) nuclear translocation and activates the Akt/PKB cell survival pathway
Zhang et al., J Immunol 2003 : RANKL stimulated IkappaB-alpha phosphorylation, IkappaB-alpha degradation and DNA binding ability of NF-kappaB were increased after over-expression of SHP-1 ( C453S )
Bharti et al., J Biol Chem 2004 : Suppression of RANKL induced NF-kappaB activation by dominant negative IkappaBalpha or by the NEMO-peptide had no effect on RANKL induced cell growth inhibition
Wang et al., J Bone Miner Res 2003 : 12-O-tetradecanoylphorbol-13-acetate ( TPA ) inhibits osteoclastogenesis by suppressing RANKL induced NF-kappaB activation ... Using a RAW ( 264.7 ) cell culture system and assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, and MAPK assays, we demonstrated that TPA inhibits osteoclastogenesis through the suppression of RANKL induced NF-kappaB activation ... Assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, protein kinase activity, and Western blotting were used to examine the effects of TPA on RANKL induced NF-kappaB , c-Jun N-terminal kinase (JNK), and MEK/ERK and p38 signal transduction pathways ... TPA alone had little effect on NF-kappaB activation in RAW ( 264.7 ) cells, but it suppresses the RANKL induced NF-kappaB activation in a dose dependent fashion ... Interestingly, the suppressive effect of TPA on RANKL induced NF-kappaB activation was prevented by a conventional PKC inhibitor, Go6976 ... Given that NF-kappaB activation is obligatory for osteoclast differentiation, our studies imply that inhibition of osteoclastogenesis by TPA is, at least in part, caused by the suppression of RANKL induced activation of NF-kappaB during an early stage of osteoclastogenesis
Guillonneau et al., J Immunol 2004 (Acute Disease...) : The role of TNF related activation induced cytokine-receptor activating NF-kappa B interaction in acute allograft rejection and CD40L independent chronic allograft rejection
Korcok et al., J Bone Miner Res 2004 : Pretreatment of rabbit osteoclasts with osteoprotegerin inhibited translocation of NF-kappaB induced by RANKL but not by BzATP, establishing that the effects of BzATP are independent of RANKL signaling
Kwak et al., Biochem Pharmacol 2004 (Bone Resorption) : M-CSF and RANKL activate the ERK, Akt, and NF-kappaB signal transduction pathways, and SCOH suppressed this activation
Kim et al., Biochem Pharmacol 2004 (Bone Resorption) : RANKL activated the ERK, Akt, and NF-kappaB signal transduction pathways in osteoclast precursor cells, and tanshinone IIA suppressed this activation
Bharti et al., J Immunol 2004 : Treatment of these cells with RANKL activated NF-kappaB, and preexposure of the cells to curcumin completely suppressed RANKL induced NF-kappaB activation ... Thus overall these results indicate that RANKL induces osteoclastogenesis through the activation of NF-kappaB , and treatment with curcumin inhibits both the NF-kappaB activation and osteoclastogenesis induced by RANKL
Jimi et al., Nat Med 2004 (Arthritis, Experimental...) : The peptide inhibited RANKL stimulated NF-kappa B activation and osteoclastogenesis both in vitro and in vivo
Ikeda et al., J Clin Invest 2004 : Although genetic and biochemical studies indicate that RANKL regulates osteoclast differentiation by activating receptor activator of NF-kappaB and associated signaling molecules, the molecular mechanisms of RANKL regulated osteoclast differentiation have not yet been fully established
Takada et al., Blood 2004 : Deletion of TNF receptors sensitized the cells to RANKL induced NF-kappaB activation, in order from least to most sensitive of p60 ( -/- ) less than p80 ( -/- ) less than p60 ( -/- ) p80 ( -/- )
Lean et al., Biochem Biophys Res Commun 2004 (Bone Resorption) : We found that AP-1, NFkappaB , and NFAT-reporter gene expression was enhanced more greatly by RANKL in RAW cells transfected with the Trx-expression construct
Ha et al., Exp Cell Res 2004 : Pretreatment of osteoclasts with the antioxidants N-acetyl-l-cystein and glutathione reduced RANKL induced Akt, NF-kappaB , and ERK activation
Zhu et al., Biochem Biophys Res Commun 2005 : RANK-L induces the expression of NFATc1, but not of NFkappaB subunits during osteoclast formation
Takatsuna et al., J Bone Miner Res 2005 (Bone Resorption) : RANKL induces activation of NF-kappaB and osteoclastogenesis in bone marrow derived monocyte/macrophage precursor cells ( BMMs ) ... ( - ) -DHMEQ strongly inhibited RANKL induced NF-kappaB activation in BMMs and inhibited RANKL induced formation of TRACP ( + ) multinucleated cells
Han et al., Blood 2005 : This RANKL-responsive region contained an NF-kappaB site that, when mutated, completely abolished the induction of NF-kappaB DNA binding activity by RANKL
Min et al., J Immunol 2005 : TRANCE induced IkappaB-alpha phosphorylation and NF-kappaB activation via a cascade of reactions involving the TNFR associated factors, phospholipase C, PI3K, and protein kinase C ( PKC-alpha and PKC-zeta )
Mangashetti et al., J Immunol 2005 (Bone Resorption...) : Interestingly, IL-4 inhibition of bone resorption occurs through prevention of RANKL induced nuclear translocation of p65 NF-kappaB subunit, and intracellular Ca ( 2+ ) changes
Yip et al., J Bone Miner Res 2005 (Calcium Signaling) : In this study, we showed a biphasic effect of TG on osteoclast formation and apoptosis through the regulation of ROS production, caspase-3 activity, cytosolic Ca2+, and RANKL induced activation of NF-kappaB and AP-1 activities ... At these lower concentrations, TG potentiated ROS production and RANKL induced NF-kappaB activity, but suppressed RANKL induced AP-1 activity and had little effect on ERK phosphorylation
Schneeweis et al., J Biol Chem 2005 : The receptor activator of NF-kappaB ( RANK ) belongs to the neuregulin/tumor necrosis factor (TNF) receptor superfamily and is activated by RANK ligand (RANK-L) , a homotrimeric, TNF-like cytokine
Lee et al., Mol Cell Biochem 2006 : Rac1 GTPase regulates osteoclast differentiation through TRANCE induced NF-kappa B activation
Amcheslavsky et al., J Cell Physiol 2006 : Since both RANKL-RANK and CpG-ODN-TLR9 interactions result in NF-kappaB activation, p38 and ERK phosphorylation, and TNF-alpha synthesis ( all implicated in osteoclastogenesis ), we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor
Kim et al., Mol Cells 2005 : Nuclear factor-kB (NF-kB) is a critical transcription factor in RANKL induced osteoclastogenesis, and electrophoretic mobility shift assays ( EMSAs ) and assay of NF-kB mediated secreted alkaline phosphatase ( SEAP ) revealed that sulforaphane selectively inhibited NF-kappaB activation induced by RANKL
Ichikawa et al., Clin Cancer Res 2006 (Bone Resorption...) : We found that treatment of monocytes with guggulsterone suppressed RANKL activated NF-kappaB activation ( as indicated by gel-shift assay ) and that this suppression correlated with inhibition of IkappaBalpha kinase and phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB
Huang et al., Cell Death Differ 2006 : Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL
Ichikawa et al., Mol Cancer Res 2006 (Bone Resorption...) : Treatment of these cells with RANKL activated NF-kappaB, and coexposure of the cells to ACA completely suppressed RANKL induced NF-kappaB activation in a time- and concentration dependent manner ... These results indicate that ACA is an effective blocker of RANKL induced NF-kappaB activation and of osteoclastogenesis induced by RANKL and tumor cells, suggesting its potential as a therapeutic agent for osteoporosis and cancer associated bone loss
Fujimura et al., Infect Immun 2006 : RANKL induced phosphorylation of ERK, p38, and NF-kappaB was not suppressed by HbR, but that of Akt was markedly suppressed
Rahman et al., J Lipid Res 2006 (Bone Resorption) : Treatment of these cells with RANKL activated nuclear factor-kappaB (NF-kappaB), and preexposure of the cells to CLA significantly suppressed RANKL induced NF-kappaB activation, including phosphorylation of I-kappaBalpha, degradation of I-kappaBalpha, and nuclear translocation of p65
Yamanaka et al., J Orthop Res 2006 (Bone Resorption) : We have also found that polymethyl methacrylate ( PMMA ) particles stimulate osteoclastogenesis, at least in part, by induction of RANKL , TNF, and by activation of NF-kappaB and MAP kinases
Chen et al., Assay Drug Dev Technol 2006 : Compound 1 did not inhibit the RANKL induced activation of a NF-kappaB reporter gene, or p38 kinase activity, suggesting a mechanism of action downstream of NF-kappaB
Feng et al., Blood 2007 (Bone Resorption...) : SDX-308 decreased constitutive and RANKL stimulated NF-kappaB activation and osteoclast formation in an osteoclast cellular model, RAW 264.7
Tintut et al., J Investig Med 2006 (Atherosclerosis...) : Binding of RANKL to its cognate receptor RANK induces NF-kappaB signaling, which stimulates osteoclastic differentiation in preosteoclasts and induces bone morphogenetic protein ( BMP-2 ) expression in chondrocytes
Nakamichi et al., J Immunol 2007 (Bone Resorption) : OPG or a soluble form of receptor activator of NF-kappaB ( the receptor of RANKL ) suppressed the release of RANKL from those cells
Fionda et al., J Immunol 2007 : 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes : role of NF-kappaB and early growth response transcription factors
Yamashita et al., J Biol Chem 2007 : Inhibition of NF-kappaB should prevent RANKL- and TNF induced bone resorption
Kim et al., Mol Pharmacol 2007 (Calcium Signaling) : Subsequent characterization of the DMS mediated suppression of osteoclastogenesis revealed that DMS did not affect RANKL induced activation of JNK, p38, NF-kappaB , and Ca2+ oscillation
Takarada et al., Eur J Pharmacol 2007 : In pre-osteoclastic cell line RAW264.7 cells, ascorbic acid similarly inhibited the formation of TRAP positive multinucleated cells, with a significant decrease in RANKL induced NF-kappaB transactivation
Mozar et al., J Cell Physiol 2008 (Bone Resorption) : Moreover, we found that Pi significantly reduced the RANKL stimulated DNA binding activity of NF-kappaB
Park et al., Int Immunopharmacol 2007 (Bone Resorption) : However, SKE did not inhibit NF-kappaB activation by RANKL
Hu et al., Eur J Pharmacol 2008 : Berberine attenuated RANKL induced activation of NF-kappaB through inhibiting phosphorylation at the activation loop of IkappaBalpha kinase beta, phosphorylation and degradation of IkappaBalpha, and NF-kappaB p65 nuclear translocation
Boissy et al., Leuk Res 2008 (Bone Resorption...) : A 3 h pulse with 25 nM bortezomib followed by a 3-day culture in its absence markedly inhibited osteoclast activity as evaluated through bone resorption, TRAcP release, and RANKL induced NF-kappaB translocation into nuclei, an event dependent on proteasomes and critical for osteoclast function
Voronov et al., Biochem Pharmacol 2008 : Benzo [ a ] pyrene inhibits osteoclastogenesis by affecting RANKL induced activation of NF-kappaB ... The results demonstrated that BaP inhibited both RANKL induced NF-kappaB activation and nuclear translocation
Tsai et al., Eur J Pharmacol 2008 : Our data suggest that paeonol inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells via attenuated of RANKL induced ERK, p38 and NF-kappaB activation, which in turn protect bone loss from ovariectomy
Kim et al., Cell Biol Int 2008 (Bone Resorption) : Interestingly, licochalcone A was shown to inhibit the RANKL induced activation of extracellular signal regulated kinase, translocation of NF-kappaB into nucleus and mRNA expression of Fra-2
Ahn et al., Int J Cancer 2008 (Breast Neoplasms...) : Together, our results indicate that simvastatin inhibits the RANKL induced NF-kappaB activation pathway that leads to suppression of osteoclastogenesis induced by RANKL and by tumor cells, thereby suggesting its therapeutic potential in osteoporosis and in cancer related bone loss
Chen et al., J Biol Chem 2008 : The lack of PLCgamma2 markedly diminished RANKL induced activation of NF-kappaB , AP-1, and NFATc1
Lin et al., Biochem Biophys Res Commun 2009 : In addition, it significantly inhibited RANKL induced NF-kappaB transcriptional activity and nuclear translocation
Sung et al., Cancer Res 2009 (Bone Resorption...) : Zerumbone abolishes RANKL induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer induced bone loss in athymic nude mice ... We found that zerumbone inhibited RANKL induced NF-kappaB activation in mouse monocyte, an osteoclast precursor cell, through inhibition of activation of IkappaBalpha kinase, IkappaBalpha phosphorylation, and IkappaBalpha degradation ... These results indicate that zerumbone is an effective blocker of RANKL induced NF-kappaB activation and of osteoclastogenesis induced by RANKL and tumor cells, suggesting its potential as a therapeutic agent for osteoporosis and cancer associated bone loss
Kim et al., J Cell Physiol 2009 (Bone Resorption) : Interestingly, saurolactam prevented RANKL induced activation of MAP kinases and NF-kappaB , and mRNA expression of osteoclast related genes and transcription factors ( c-Fos, Fra-2, and NFATc1 )
Ang et al., J Cell Physiol 2009 (Bone Resorption) : Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL induced NF-kappaB and NFAT activity ... CAPE inhibited both constitutive and RANKL induced NF-kappaB and NFAT activation, concomitant with delayed IkappaBalpha degradation and inhibition of p65 nuclear translocation
Maruyama et al., J Bone Miner Res 2010 : RANKL still induced the degradation of I kappaB alpha and activated classical NF-kappaB , whereas processing of p100 to p52 was abolished by the aly/aly mutation
Xu et al., Antioxid Redox Signal 2010 : Concurrently, PAMM expression completely abolished RANKL induced p100 NF-kappaB and c-Jun activation, as well as osteoclast formation
Wang et al., Bone 2010 (Bone Resorption) : Calcitonin-gene related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption ... These results suggest that CGRP signaling maintains bone mass both by directly stimulating stromal cell osteoblastic differentiation and by inhibiting RANKL induced NF-kappaB activation, osteoclastogenesis, and bone resorption
Kalliolias et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid...) : IL-27 inhibited human osteoclastogenesis, suppressed the induction of NFATc1, down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ), and inhibited RANKL mediated activation of ERK, p38, and NF-kappaB in osteoclast precursors
Luckprom et al., J Periodontal Res 2010 (Bone Resorption) : A cAMP dependent protein kinase inhibitor, H89, and a nuclear factor kappaB (NF kappaB) inhibitor, pyrrolidine dithiocarbamate, inhibited RANKL expression, prostaglandin E ( 2 ) production and NF kappaB translocation
Trebec-Reynolds et al., J Cell Biochem 2010 : In turn, Hif1alpha mRNA levels are induced by RANKL mediated activation of NF-kappaB
Wong et al., J Biol Chem 1998 : The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor ... The TRANCE receptor (TRANCE-R) , recently identified as receptor activator of NF-kappabeta ( RANK ), activates NF-kappaB , a transcription factor critical in the differentiation and activation of those cells ... In this report we identify the TNF receptor associated factor (TRAF) family of signal transducers as important components of TRANCE-R mediated NF-kappaB activation ... Dominant negative forms of TRAF2, TRAF5, and TRAF6 and an endogenous inhibitor of TRAF2, TRAF interacting protein (TRIP), substantially inhibited TRANCE-R mediated NF-kappaB activation, suggesting a role of TRAFs in regulating DC and osteoclast function
Galibert et al., J Biol Chem 1998 : An NH2-terminal truncation mutant of TRAF6 inhibited RANKL mediated NF-kappaB activation, but failed to affect constitutive signaling induced by receptor overexpression, revealing a selective role for TRAF6 in ligand induced activation events