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BCL3 — CNTN2

Text-mined interactions from Literome

Mori et al., Virus Genes 2001 (Leukemia, T-Cell) : We have recently demonstrated that Tax induces the constitutive expression of the anti-apoptotic protein, Bcl-xL , in a mouse T-cell line ... We thus examined whether Tax also activates the expression of Bcl-xL in human T-cells ... Expression of Tax in a human T-cell line, Jurkat, induced the expression of the Bcl-xL gene, but did not significantly affect the expression of the other apoptosis related genes, Bcl-2 and Bax ... Transient transfection assays showed that Tax stimulated human Bcl-xL promoter activity in Jurkat cells
Hishiki et al., J Biol Chem 2007 : In addition to stimulating transcription from the HTLV-1 LTR, Tax also enhances BCL3 expression ; thus, transcription from the LTR is regulated by both positive and negative feedback mechanisms
Kim et al., J Virol 2008 : The proto-oncogene Bcl3 , induced by Tax , represses Tax mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoter ... We found that Tax induced Bcl3 expression through stimulation of the NF-kappaB pathway ... Importantly, Bcl3 associated with the HTLV-1 promoter in a Tax dependent manner and inhibited the binding of the critical cellular coactivator p300 ... Together, these data suggest that Tax induced Bcl3 overexpression benefits the virus in two important ways