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CDKN1A — ID2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Matsumura et al., J Biol Chem 2002
:
Id2 enhancement of SMC growth and
inhibition of
p21 expression were dependent on phosphorylation of Id2 by cyclin E/cdk2, as an Id2 cDNA containing a mutation in the cdk2 phosphorylation site ( serine 5 ) failed to regulate SMC cell cycle progression or p21 promoter activity
Kim et al., Mol Cell Biol 2006
:
In vitro studies with nuclear localization sequence tagged Id2 revealed that the nuclear localization of
Id2 itself is
critical for the downregulation of
p21 promoter activity
Fan et al., Kidney Int 2012
(Disease Models, Animal...) :
The loss of Pkd1 caused an upregulation of the inhibitor of differentiation 2 (Id2), a transcription regulator, triggering an
Id2 mediated downregulation of
p21 in mutant mouse embryonic kidney cells in vitro