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CKM — TP53
Text-mined interactions from Literome
Jackson et al., Gene Expr 1995
:
p53 dependent activation of the mouse
MCK gene promoter : identification of a novel p53-responsive sequence and evidence for cooperation between distinct p53 binding sites
Zhao et al., Mol Cell Biol 1994
:
Conversely, mouse wild-type
p53 strongly
activated the rat
CKM promoter in CV-1 cells but not in HeLa cells, suggesting that, in CV-1 cells, p53 may associate with a required coactivator or is modified in a manner necessary for CKM activation
Sehgal et al., Oncogene 1993
:
In HeLa cells, although wt
p53 activated p50-2 but
repressed the
MCK and IL-6 promoters, p53 Val135 activated all three reporters
Zhao et al., Oncogene 1996
:
In this report, we employed the gel-shift assay and demonstrated that recombinant, immunoaffinity purified mouse
p53wt binds to this 112 bp CKM sequence and
activates the in vitro transcription of the proximal
CKM promoter by nuclear extracts from CV-1 cells ... The results are discussed in relation to the possible
role of
p53wt in the expression of
CKM in cell types which may not express the myogenic transcription factors
Jackson et al., Oncogene 1998
:
Synergistic transcriptional
activation of the
MCK promoter by
p53 : tetramers link separated DNA response elements by DNA looping
Tamir et al., Oncogene 1998
:
In this study we tested the
involvement of
p53 in the activation of
MCK transcription during muscle differentiation of C2 cells ... The expression of a dominant negative
p53 protein in muscle cells
reduced the expression of endogenous
MCK gene