◀ Back to IGF1

COL2A1 — IGF1

Text-mined interactions from Literome

Boehm et al., Arthritis Rheum 2007 : Inhibition of Hsp90 with 100 nM or 500 nM geldanamycin blocked IGF-1 induced cell proliferation, Akt and p42/44 activation, and COL2A1 expression
Fernandez-Cancio et al., Growth Horm IGF Res 2008 : IGF-I stimulated IGF-I, IGFBP3, SOX9, COL2A1 and aggrecan expression whereas it inhibited IGF-IR expression
Zhang et al., Osteoarthritis Cartilage 2009 (MAP Kinase Signaling System) : IGF-1 increased Col2a1 mRNA expression in rat endplate chondrocytes in a time- and dose dependent manner ... The PI3K inhibitor Wartmannin significantly inhibited the IGF-1 effect on Col2a1 mRNA expression but did not affect IGF-1 induced repression of MMP-13 expression ... In contrast, the ERK/MAPK inhibitor PD98059 significantly inhibited the effect of IGF-1 on MMP-13 mRNA repression and enhanced IGF-1 induced Col2a1 mRNA expression
Fernández-Cancio et al., Growth Horm IGF Res 2009 : IGF-I stimulated IGF-I, IGFBP-3, SOX9, COL2A1 and aggrecan expression and opposed COL2A1 and aggrecan gene expression inhibition by VitD
Renard et al., J Mol Med (Berl) 2012 : These data demonstrate the role of Sox9, Sp1/Sp3, and euchromatin associated factors ( p300, Tip60 ) in the IGF-I induced upregulation of COL2A1 , indicating possible use of this growth factor in articular cartilage engineering applications to promote repair in patients with degenerative diseases, such as osteoarthritis
Koshimizu et al., J Biol Chem 2012 : Knockdown of vinculin in the metatarsal organ culture abrogated the IGF-I induced growth and inhibited the up-regulation of Col2a1 and aggrecan expression by IGF-I