◀ Back to MAPK1
CAPN2 — MAPK1
Pathways - manually collected, often from reviews:
-
BioCarta mcalpain and friends in cell motility:
ERK2 (MAPK1)
→
Calpain2 complex (CAPNS1-CAPN2)
(modification, activates)
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/ERK2/m-calpain complex (PTK2-YES1_SRC_FYN-MAPK1-CAPN2)
→
ERK2 (MAPK1)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/ERK2/m-calpain complex (PTK2-YES1_SRC_FYN-MAPK1-CAPN2)
→
FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/ERK2/m-calpain complex (PTK2-YES1_SRC_FYN-MAPK1-CAPN2)
→
m-calpain (CAPN2)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
ERK2 (MAPK1)
→
m-calpain (CAPN2)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
-
NCI Pathway Database ErbB1 downstream signaling:
Erk1-2-active (MAPK3/MAPK1)
→
m-calpain (CAPN2)
(modification, activates)
Glading et al., J Biol Chem 2000*, Glading et al., J Biol Chem 2001*, Glading et al., Mol Cell Biol 2004*
Evidence: assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Su et al., J Mol Biol 2010
(MAP Kinase Signaling System) :
Collectively, our data reveal that excessive TRPM7 channel activity causes oxidative and nitrosative stresses, producing cell rounding mediated by p38
MAPK/JNK dependent activation of
m-calpain
Zadran et al., J Neurosci 2010
:
In both cell types, BDNF and EGF rapidly elicited
calpain activation, which was completely
blocked by
MAPK and calpain inhibitors
Hollborn et al., PloS one 2013
:
The cytotoxic effect of curcumin involved
activation of caspase-3 and
calpain , intracellular calcium signaling, mitochondrial permeability, oxidative stress, increased phosphorylation of p38
MAPK and decreased phosphorylation of Akt protein