◀ Back to NEUROD2
NEUROD2 — REST
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Immaneni et al., Nucleic Acids Res 2000
:
REST-VP16 activates multiple
neuronal differentiation genes in human NT2 cells ... However, REST/NRSF ( -/- ) mice suggest that the absence of
REST/NRSF dependent repression alone is not
sufficient for the expression of these
neuronal differentiation genes and that the presence of other promoter/enhancer-specific activators is required
Watanabe et al., Genes Dev 2004
:
Here we show that the expression of
REST-VP16 in myoblasts grown under muscle differentiation conditions blocked entry into the muscle differentiation pathway, countered endogenous REST/NRSF dependent repression, activated the REST/NRSF target genes, and, surprisingly,
activated other
neuronal differentiation genes and converted the myoblasts to a physiologically active neuronal phenotype
Su et al., Mol Cell Biol 2004
(Calcium Signaling) :
Activation of
REST/NRSF target genes in neural stem cells is
sufficient to cause
neuronal differentiation ... These results showed that direct activation of
REST/NRSF target genes in NSCs with a single transgene, REST-VP16, is
sufficient to cause
neuronal differentiation , and the findings suggested that direct activation of genes involved in the terminal stage of differentiation may cause neuronal differentiation of NSCs
Salani et al., J Neurochem 2009
(Brain Neoplasms...) :
Acetylcholine induced
neuronal differentiation : muscarinic receptor activation
regulates EGR-1 and
REST expression in neuroblastoma cells