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AR — IGF1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Papatsoris et al., Trends Mol Med 2005
(Prostatic Neoplasms) :
Moreover, it has been suggested that
IGF-1 induces ligand independent activation of the
androgen receptor and enhances the expression of matrix metalloproteinase-2 and urokinase plasminogen activator
Wu et al., Clin Cancer Res 2005
(Prostatic Neoplasms) :
Our findings also suggest an
IGF-IR dependent activity of the
androgen receptor in androgen independent prostate cancer cells
Hulmi et al., J Steroid Biochem Mol Biol 2008
:
The purpose of this study was to examine the impact of protein ingestion on circulating testosterone and muscle
androgen receptor (AR) as well as on
insulin-like growth factor-I ( MGF and IGF-IEa )
responses to a resistance exercise ( RE ) bout in ( 57-72 year ) men
Dillon et al., J Clin Endocrinol Metab 2009
:
Basal
IGF-I protein expression
increased in SUP after 3 months ( P = 0.05 ), with no changes in
androgen receptor or total and phosphorylated Akt, mammalian target of rapamycin, S6 kinase, and 4E-binding protein
Schayek et al., Clin Cancer Res 2009
(Prostatic Neoplasms) :
Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (
IGF-IR ) gene transcription in an
androgen receptor dependent manner
Kim et al., Mol Cells 2009
:
Insulin-like growth factor-I induces
androgen receptor activation in differentiating C2C12 skeletal muscle cells
Lee et al., Mol Cells 2009
:
Insulin-like growth factor-I induced
androgen receptor activation is mediated by the PI3K/Akt pathway in C2C12 skeletal muscle cells
Kim et al., Mol Cells 2009
:
Ligand independent
activation of the
androgen receptor by
insulin-like growth factor-I and the role of the MAPK pathway in skeletal muscle cells
Sayeed et al., J Cell Physiol 2012
:
In addition, we demonstrate that
IGFI mediated activation of
androgen receptor (AR) , known to occur in prostate cancer cells, requires expression of ß ( 1A ) integrins as evaluated by luciferase reporter assays and immunoblotting analysis
Huang et al., Nutr Cancer 2011
(Prostatic Neoplasms) :
These results demonstrated that Zyflamend inhibited
IGF-1 stimulated cell growth, IGF-1R expression, and
androgen receptor expression and its nuclear localization, but these effects were not dependent upon phosphatidylinositol 3-kinase/pAKT signaling
Chi et al., Clin Cancer Res 2012
(Disease Progression...) :
PSA declines in treatment-naive patients were observed, potentially mediated by
IGF-IR effects on
androgen receptor expression
Culig et al., Prostate 1996
(Disease Models, Animal...) :
IGF-I in particular, other growth factors as well, can
activate the
androgen receptor