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Medyouf et al., J Exp Med 2011
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
Furthermore, IGF1R is a Notch1 target, and Notch1 signaling is required to maintain IGF1R expression at high levels in T-ALL cells
Villanueva et al., Gastroenterology 2012
(Carcinoma, Hepatocellular...) :
These samples had altered expression in Notch pathway genes and activation of insulin-like growth factor signaling, despite a low frequency of mutations in regions of NOTCH1 associated with cancer