Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PRKCZ
→
PDPK1
(directlyIncreases, PDPK1 Activity, PRKCZ Activity)
Standaert et al., Biochemistry 2001* Evidence: Our findings suggest that insulin, via PIP(3), provokes increases in PKC-zeta enzyme activity through (a) PDK-1-dependent T410 loop phosphorylation, (b) T560 autophosphorylation
OpenBEL Selventa BEL large corpus:
PRKCZ
→
PDPK1
(increases, PRKCZ Activity)
Evidence: Once at the plasma membrane, Akt and PKCz/l are phosphorylated and activated by PDK1