LaDu et al., Neurochem Int 2001
(Encephalitis) :
Experiments using receptor associated protein (RAP) , an inhibitor of apoE receptors with a differential affinity for the low-density lipoprotein receptor (LDLR) and the LDLR related protein (LRP), revealed that LRP mediates A beta induced glial activation, while LDLR mediates the A beta induced changes in apoE levels
Fan et al., J Lipid Res 2011
:
Receptor-associated-protein (RAP) mediated inhibition of apoE receptor function blocked appearance of the 8.1 nm species, suggesting that this particle may arise through apoE recycling
Medh et al., J Biol Chem 1995
:
Because LDL bind via apolipoprotein ( apo) B100 whereas VLDL bind via apoE, our results show that RAP inhibits LDL receptor interactions with both apoB100 and apoE