Gene interactions and pathways from curated databases and text-mining

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CASP7 — FAF1

Pathways - manually collected, often from reviews:

  • BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → Caspase 7 (CASP7) (modification, activates)
  • BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → Caspase 7 (active) (CASP7) (modification, activates)

Text-mined interactions from Literome

Ryu et al., Biochem Biophys Res Commun 2001 : Subsequent analysis revealed that overexpression of hFAF1 induced nuclear condensation, appearance of phosphatidylserines in the outer leaflet of the cellular membrane, and caspase 3 activation
De Zio et al., Cell Mol Life Sci 2008 : Faf1 is expressed during neurodevelopment and is involved in Apaf1 dependent caspase-3 activation in proneural cells