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HRG — RAC2

Text-mined interactions from Literome

Yang et al., Mol Cell Biol 2006 (Breast Neoplasms) : In breast cancer cells, heregulin beta1 (HRG) causes a strong activation of Rac ; however, it does so with striking differences in kinetics compared to epidermal growth factor, which signals through ErbB1 ( epidermal growth factor receptor [ EGFR ] ) ... Using specific ErbB receptor inhibitors and depletion of receptors by RNA interference ( RNAi ), we established that, surprisingly, activation of Rac by HRG is mediated not only by ErbB3 and ErbB2 but also by transactivation of EGFR, and it is independent of ErbB4 ... HRG induced Rac activation was phosphatidylinositol 3-kinase dependent and Src independent
Yang et al., Biochem J 2008 (Breast Neoplasms) : Inhibition of EGFR, PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also blocked the up-regulation of cyclin D1 and p21(Cip1) by HRG