Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
TP53
→
Complex of ITGAV-ITGB3
(decreases, ITGAV/ITGB3 Activity, TP53 Activity)
Soldi et al., EMBO J 1999 Evidence: Integrin avb3 is expressed in high quantities on angiogenic endothelial cells (Brooks et al., 1994a), where it suppresses the activity of p53 and the p53-inducible cell-cycle inhibitor p21WAF1/CIP1 and increases the Bcl-2:Bax ratio, with a consequent antiapoptotic effect (Stromblad et al., 1996).
OpenBEL Selventa BEL large corpus:
TP53
→
Complex of ITGAV-ITGB3
(decreases, TP53 Activity)
Evidence: In addition, avb3 has been shown to bind MMP-2, in an RGD-independent way, thereby localizing MMP-2-mediated matrix degradation to the endothelial cell surface (28, 58). avb3 is nearly undetectable on quiescent endothelium, but is highly upregulated during cytokine or tumor-induced angiogenesis. In activated endothelium avb3 suppresses the activity of both p53 and the p53-inducible cell-cycle inhibitor p21WAF1/CIP1, while increasing the Bcl2:Bax ratio, resulting in an anti-apoptotic effect (226)...