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TP53 — TP63

Pathways - manually collected, often from reviews:

• FastForward regulation: TP53 → TP63 (transcriptional regulation, unknown) Harmes et al., Oncogene 2003*
  Evidence: DNABINDING
• NCI Pathway Database Direct p53 effectors: p53 (tetramer) complex (TP53) → DeltaNp63 alpha (TP63) (transcription, activates) Harmes et al., Oncogene 2003*
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TP63 — TP53 (physical association, affinity chromatography technology) Lu et al., J Biol Chem 2013*
• IRef Hprd Interaction: TP53 — TP63 (in vivo) Gaiddon et al., Mol Cell Biol 2001*
• IRef Intact Interaction: Complex of TP53-TP63-SMAD2-TP53-TP63-TP53-SMAD2-TP63-SMAD2 (physical association, anti bait coimmunoprecipitation) Adorno et al., Cell 2009*
• IRef Intact Interaction: TP63 — TP53 (physical association, anti bait coimmunoprecipitation) Girardini et al., Cancer Cell 2011*
• IRef Intact Interaction: TP63 — TP53 (physical association, anti bait coimmunoprecipitation) Adorno et al., Cell 2009*
• MIPS Negatome - no physical interaction between proteins Interaction: TP53 — TP63 (Absence of interaction, coimmunoprecipitation) Li et al., Oncogene 2008*

Text-mined interactions from Literome

Shimada et al., Cancer Res 1999 : We found that p51/p63 trans activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53
Senoo et al., Br J Cancer 2001 (Carcinoma, Squamous Cell...) : Transient co-transfection data indicate the possibility that DeltaNp73L can inhibit p53- , and more preferentially, p51 mediated transactivation
Cam et al., Cancer Cell 2006 (Rhabdomyosarcoma) : Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state