Gene interactions and pathways from curated databases and text-mining

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PRG4 — SPP1

Text-mined interactions from Literome

Yumoto et al., Proc Natl Acad Sci U S A 2002 (Arthritis...) : In contrast, OPN deficiency prevented the mice from such surface destruction, loss of proteoglycan in the articular joint cartilage, and swelling of the joints even when the mice were subjected to mAbs/LPS injection
Rickard et al., J Cell Biochem 2003 : In hFOB/ERalpha9 cells, both genistein and E ( 2 ) increased the endogenous gene expression of the progesterone receptor (PR), the proteoglycan versican, and alkaline phosphatase ( AP ), but inhibited osteopontin (OP) gene expression and interleukin-6 (IL-6) protein levels