Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CDK4
→
FOXO3
(decreases, CDK4 Activity)
Evidence: TABLE 3 Genes involved in proliferation and cell cycle regulation that are repressed by FOXO3.A3.ER and FOXO3.A3.ER.H212R as identified by functional annotation clustering. Affymetrix HG-U133 Plus 2.0 arrays according to the manufacturer?s instructions (Affymetrix, Santa Clara, CA).A Custom CDF Version 11 with Entrez-based gene definitions was used to annotate the arrays (28). Raw fluorescence intensity values were normalized, applying quantile normalization. Differential gene expression was an...