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CD40 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CD40 → TNF (increases)
  Evidence: In the presence of pro-inflammatory cytokines such as tumor necrosis factor-? (TNF-?) and/or interferon-gamma (IFN-G), endothelial cell CD40 expression is markedly enhanced [6]. These cytokines, especially when combined, also induce CD40 expression in rat vascular SMC [7].
• OpenBEL Selventa BEL large corpus: CD40 → TNF (increases)
  Evidence: Human CASMCs (coronary artery smooth muscle cells) in culture exposed to IL (interleukin)-1beta or TNF-alpha (tumour necrosis factor-alpha) had increased superoxide generation and enhanced CD40 expression, detected by EPR (electron paramagnetic resonance) and immunoblotting respectively.
• OpenBEL Selventa BEL large corpus: CD40 → TNF (increases)
  Evidence: TNF and IFN-g were found to be the most effective at enhancing CD40 expression, producing about a 3-fold increase in CD40 expression after 24 h (Fig. 1). IFN-beta and IL-1a also increased CD40 expression, although somewhat less effectively than TNF or IFN-g.
• OpenBEL Selventa BEL large corpus: CD40 → TNF (increases) Möttönen et al., Br J Rheumatol 1998*
  Evidence: TNF-alpha upregulated the expression of CD40 on SF macrophages.

Text-mined interactions from Literome

Suttles et al., J Biol Chem 1999 : Together, the data demonstrate that CD40 mediated induction of IL-1beta and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-10
von Leoprechting et al., Cancer Res 1999 (Melanoma) : CD40 expression could be enhanced in CD40 positive MM by stimulation with IFN-gamma and tumor necrosis factor-alpha but not by interleukin (IL)-1beta or CD40 triggering ... CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a , and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Harigai et al., J Rheumatol 1999 (Arthritis, Rheumatoid) : Ligation of CD40 induced tumor necrosis factor-alpha in rheumatoid arthritis : a novel mechanism of activation of synoviocytes ... IL-10 exerted inhibitory effects on both CD40 ligation induced and CD40 ligation plus IFN-gamma induced TNF-alpha production by ST cells
Chabot et al., J Immunol 1999 : By also measuring TNF-alpha levels, specificity of cytokine regulation was observed ; while anti-CD40 and CTLA-4-Fc reduced IL-10 and TNF-alpha levels, anti-CD23 did not affect TNF-alpha while attenuating IL-10 generation
Tan et al., J Neuroimmunol 1999 (Multiple Sclerosis) : We also find that ligation of microglial CD40 by CD40L triggers a significant production of TNF-alpha
Salgado et al., J Leukoc Biol 1999 : Tumor necrosis factor alpha (TNF-alpha) enhanced CD40 expression on LC during culture
Pype et al., J Biol Chem 2000 : CD40 signaling involves the recruitment of TNF receptor associated factors (TRAFs) to its cytoplasmic domain
Arrighi et al., J Immunol 2001 (Dermatitis, Allergic Contact) : SB203580, an inhibitor of the p38 MAPK, but not the extracellular signal regulated kinase l/2 pathway blocker PD98059, inhibited the up-regulation of CD1a, CD40 , CD80, CD86, HLA-DR, and the DC maturation marker CD83 induced by LPS and TNF-alpha
Chabot et al., J Neurosci Methods 2001 (Central Nervous System Diseases...) : Morphological features and mechanisms of cytokine production resemble those observed in microglia -- T cell co-cultures since CTLA-4 and CD40 -- CD40L blockades reduce TNF-alpha and IL-10 levels, while anti-CD23 inhibits IL-10 only in U937 -- T cell interactions
Brown et al., J Exp Med 2001 : Differential signaling and tumor necrosis factor receptor associated factor ( TRAF ) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)
Kitagawa et al., J Rheumatol 2001 (Arthritis, Rheumatoid) : We examined the effects of IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and granulocyte-macrophage colony stimulating factor ( GM-CSF ) on CD40 expression on CD68+ synovial macrophage-lineage cells ( SMC )
Manning et al., Eur J Immunol 2002 : The specific TRAF dependency of CD40 induced growth arrest, TNF-alpha production, and phosphorylation of signaling molecules are shown, while p38 MAPK activation and cell surface antigen modulation suggest TRAF independent CD40 signaling in B cells
Foey et al., Cytokine 2001 : CD40 ligation induces macrophage IL-10 and TNF-alpha production : differential use of the PI3K and p42/44 MAPK-pathways ... IL-10 and tumour necrosis factor alpha (TNF-alpha) are produced by macrophage colony stimulating factor ( M-CSF ) -primed monocytes/macrophages in response to CD40 ligation ... These observations suggest that CD40 ligation induces macrophage IL-10 and TNF-alpha production, the mechanism of which is p70S6K dependent yet bifurcates at the level of PI3K and p42/44 MAPK
Jana et al., J Neurochem 2002 : Regulation of tumor necrosis factor-alpha expression by CD40 ligation in BV-2 microglial cells ... This study delineates the mechanism by which CD40 ligation regulates the expression of TNF-alpha in BV-2 microglial cells ... There was very little induction of TNF-alpha by ligation of CD40 alone by either cross linking antibodies against CD40 or recombinant CD40 ligand ( CD154 ) ... However, CD40 ligation markedly induced the production of TNF-alpha as well as the expression of TNF-alpha mRNA in interferon-gamma (IFN-gamma) stimulated BV-2 glial cells ... Ligation of CD40 in CD40 overexpressed cells markedly enhanced the expression of TNF-alpha in the presence of IFN-gamma ... However, CD40 ligation alone in the presence or absence of CD40 overexpression induced the activation of only NF-kappaB and not that of C/EBPbeta, suggesting that the activation of NF-kappaB alone by CD40 ligation is not sufficient to induce the expression of TNF-alpha and that the activation of C/EBPbeta is also necessary for strong induction of TNF-alpha ... Taken together, these studies suggest that activation of both NF-kappaB and C/EBPbeta is important for strong induction of TNF-alpha and that CD40 ligation regulates the expression of TNF-alpha by modulating the activation of only NF-kappaB but not that of C/EBPbeta
Iwata et al., Invest Ophthalmol Vis Sci 2002 : In contrast, TNF-alpha enhanced CD40 on HCE but not on HCS cells
Liu et al., Autoimmunity 2001 (Arthritis, Rheumatoid) : For investigating the effect of CD40 expressed on synovial fibroblasts on TNF-alpha production in joint compartment, we used anti-CD40 antibody to bind CD40 on fibroblasts for one hour and then co-cultured with synovial fluid mononuclear cells
Hostager et al., J Immunol 2002 : Here we demonstrate that CD40 induced TNF stimulates IgM production through CD120b and that CD120b signaling is required for optimal CD40 induced IgM secretion
Companjen et al., Int Immunol 2002 : IL-6, IL-8, tumor necrosis factor (TNF)-alpha , IL-12 and IL-1 beta were induced upon CD40 ligation and IFN-gamma stimulation, while IL-10 could be induced by CD40 ligation alone and was reduced again by the addition of IFN-gamma ... These data show that CD40 ligation induced secretion of IL-6 and IL-8, but not TNF-alpha and IL-10, is partially mediated via IL-1 and that IL-1 plays a prominent role in the inflammatory response initiated by CD40 ligation in intact human skin
Basaki et al., Arch Biochem Biophys 2002 (Burkitt Lymphoma) : CD40 mediated tumor necrosis factor receptor associated factor 3 signaling upregulates IL-4 induced germline Cepsilon transcription in a human B cell line
Hong et al., Kidney Int 2002 : TNF-alpha up-regulated C3, CD40 and B7h production by PTEC
Wagner et al., Arterioscler Thromb Vasc Biol 2002 : Reverse transcription-polymerase chain reaction and Western blot analysis revealed that treatment of either cell type with atorvastatin, cerivastatin, or pravastatin ( 1 to 10 micromol/L ) inhibited interferon-gamma plus tumor necrosis factor-alpha stimulated CD40 expression by approximately 50 %, an effect that was not reversed by the HMG-CoA reductase product mevalonic acid ( 400 micromol/L )
Verma et al., Circulation 2003 : The effects of resistin on expression of vascular cell adhesion molecule ( VCAM-1 ) and monocyte chemoattractant chemokine ( MCP-1 ) were studied in addition to CD40 receptor, CD40 ligand induced MCP-1 expression, and tumor necrosis factor receptor associated factor-3 ( TRAF3 ), an inhibitor of CD40 signaling
Galy et al., J Immunol 1992 : IL-1 alpha, TNF-alpha , IFN-gamma, but not IL-4, significantly up-regulated the membrane expression of CD40 on cultured TEC
Haxhinasto et al., J Biol Chem 2004 : Synergistic B cell activation by CD40 and the B cell antigen receptor : role of B lymphocyte antigen receptor mediated kinase activation and tumor necrosis factor receptor associated factor regulation
Wagner et al., J Immunol 2004 : Similar to CpG ODN, CD40 ligand (CD40L) alone induced IL-6, TNF-alpha , and IL-10
De Saint Jean et al., Exp Eye Res 2004 : In the primary cultured cells, TNFalpha induced an important upregulation of ICAM-1, Fas and CD40 whereas CD44 and CD63 were significantly decreased
Burger et al., J Immunol 2004 : The production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN-gamma-macrophages only ... Finally, anti-CD40L Abs failed to inhibit TNF and IL-1beta production induced in IFN-gamma-macrophages by solubilized membranes, whereas TNF production induced by CD40LT was inhibited
Orange et al., J Allergy Clin Immunol 2004 (Ectodermal Dysplasia...) : Immunologic function was variably impaired, with reduced CD40 induced B-cell proliferation, partially reduced NF-kappa B p65 nuclear translocation, and variable Toll-like receptor induced TNF production
Horai et al., J Clin Invest 2004 (Arthritis, Experimental...) : We found that TNF-alpha induced OX40 expression on T cells and blocking the interaction between either CD40 and its ligand or OX40 and its ligand suppressed development of arthritis
Burgess et al., J Allergy Clin Immunol 2005 (Asthma) : TNF-alpha increased expression of both CD40 and OX40 ligand on both asthmatic and nonasthmatic airway smooth muscle cells ... IL-1beta alone had no effect, but it attenuated the TNF induced expression of both CD40 and OX40 ligand
Nunes et al., Microbes Infect 2005 (Genetic Predisposition to Disease...) : CD40 engagement induced comparable TNF-alpha production in macrophages from both strains
Yamagishi et al., Drugs Exp Clin Res 2005 : Nifedipine completely inhibited TNF-alpha induced upregulation of CD40 mRNA levels in HUVEC
Zhou et al., Hepatology 2005 (Hepatitis) : These in vitro studies demonstrated that TNF-alpha induces CD40 expression in hepatocytes and that subsequent activation of CD40 results in hepatocyte apoptosis mediated at least in part by enhanced hepatocyte expression of FasL
Lee et al., Proc Natl Acad Sci U S A 2005 (Diabetes Mellitus, Experimental...) : Moreover, neonatal treatment with TNF-alpha resulted in skewed development of a CD8alpha ( + ) CD11b ( - ) CD11c ( + ) DC subset such that TNF-alpha decreases the CD8alpha ( + ) CD11c ( + ) DC subset, increases the CD11c ( + ) CD11b ( + ) subset, and causes an increase in the expression of CD40 and CD54 on mature DCs capable of inducing immunity
Ehrhart et al., Journal of neuroinflammation 2005 : Further, this stimulation was also able to suppress microglial TNF-alpha and nitric oxide production induced either by IFN-gamma or Abeta peptide challenge in the presence of CD40 ligation
Danese et al., J Immunol 2006 (Crohn Disease) : In vitro infliximab prevented TNF-alpha induced CD40 and VCAM-1 expression by HIMEC, and reduced PBT, but not platelet, surface CD40L expression and sCD40L release
Subauste et al., Infect Immun 2006 (Toxoplasmosis, Animal) : In vivo CD40 ligation enhanced tumor necrosis factor alpha (TNF-alpha) production by T. gondii infected macrophages ... In addition, CD40 stimulation required the presence of TNF receptor 2 to reduce parasite load in vivo
Qian et al., Eur J Immunol 2006 : TNF-alpha significantly induced B7-H2 and CD40 expression by A549 cells, but had no effect on B7-1 or B7-2 expression
Eljaafari et al., Leukemia 2006 (Leukemia, Myeloid, Acute) : Protein fractionation, blockade experiments and exogenous cytokine reconstitution demonstrated the involvement of TNF in the upregulation of CD54, CD40 and HLA-class II molecules, and of IFNgamma in the increase of HLA-class I and class II molecule expression
Lin et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 : Fenofibrate inhibits tumor necrosis factor-alpha induced expression of CD40 and matrix metalloproteinase in human vascular endothelial cells ... To investigate the regulatory effects of fenofibrate on TNF-alpha induced CD40 expression and matrix metalloproteinase ( MMP ) activity in human vascular endothelial cells ( HUVECs ) ... Quantitative RT-PCR and flow cytometry were employed to evaluate the effect of fenofibrate on TNF-alpha induced CD40 mRNA and cell surface CD40 expression in HUVECs, and gelatin zymography was used to determine the effect of fenofibrate on the gelatinolytic activities of MMP-2 and MMP-9 in TNF-alpha stimulated HUVECs ... Fenofibrate at the concentrations of 5x10 ( -5 ), 1x10 ( -4 ) and 2x10 ( -4 ) mol/L significantly reduced TNF-alpha induced increment of CD40 mRNA and cell surface CD40 expressions ( P < 0.01 ), with the maximal inhibition achieved at the concentration of 1x10 ( -4 ) mol/L. Fenofibrate at 2x10 ( -4 ) mol/L did not further decrease CD40 expression induced by TNF-alpha
Murugaiyan et al., J Immunol 2006 (Neoplasms, Experimental) : IL-10 prevents the CD40 induced CTL and TNF-alpha and IL-12 production, Th1 skewing, and tumor regression
D'Alimonte et al., J Immunol 2007 : Guanosine effects were mediated by an increased phosphorylation of Akt, a PI3K downstream effector, as well as of ERK1/2 and p38 in the MAPK system, because culture pretreatment with selective ERK1/2, p38 MAPK, and PI3K antagonists ( U0126, SB203580, or LY294002, respectively ) counteracted guanosine inhibition on IFN-gamma/TNF-alpha induced CD40 expression and function as well as on STAT-1alpha or NF-kappaB nuclear translocation
Zirlik et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : This study investigated the involvement of tumor necrosis factor receptor associated factors ( TRAFs ) in CD40 signaling in endothelial cells ( ECs ) and their expression in atheromata and cells involved in atherogenesis
Meers et al., Leukemia 2007 (Disease Progression...) : In addition, stimulation of the CD40 receptor on purified PB monocytes led to a significantly higher tumor necrosis factor alpha production in patients
Miyazawa et al., J Toxicol Sci 2008 : While recombinant human TNF-alpha augmented CD54 and CD40 expression in a dose dependent manner, rhTNF-alpha did not increase CD86 expression
Rezai-Zadeh et al., Journal of neuroinflammation 2008 (Encephalitis) : Apigenin and luteolin also suppressed microglial TNF-alpha and IL-6 production stimulated by IFN-gamma challenge in the presence of CD40 ligation
Troeger et al., Klin Padiatr 2008 (Blast Crisis...) : We therefore determined the baseline expression and CD40 mediated modulation of TNF receptor and costimulatory molecules in 5 patients with proB-ALL, 8 with preB-ALL and 22 with c-ALL performing FACS analysis ... Here, we demonstrate for the first time a significantly lower baseline expression and CD40 induced modulation capacity of TNF receptor and costimulatory molecules in pediatric proB-ALL compared to more mature precursor B-ALL blasts
Krimmer et al., Allergy 2009 (Asthma) : The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expression ... Interferon-gamma and TNF-alpha synergistically increased CD40 expression to a greater extent on asthmatic than on nonasthmatic ASM ... TNF-alpha and IFN-gamma induced CD40 via nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-3 in both cell types and modulated OX40L via NF-kappaB and c-Jun N terminal kinase in nonasthmatic cells
Aronchik et al., Cancer Res 2010 (Breast Neoplasms) : The I3C dependent accumulation of full-length unprocessed CD40 protein caused a shift in CD40 signaling through TNF receptor associated factors (TRAF) , including the TRAF1/TRAF2 positive regulators and TRAF3 negative regulator of NF-kappaB transcription factor activity
Tawfeek et al., PloS one 2010 (Bone Resorption) : PPR dependent stimulation of TNF production by T cells and the resulting TNF regulation of CD40 signaling in SCs are potential new therapeutic targets for the bone loss of hyperparathyroidism
Mavroudi et al., J Leukoc Biol 2011 (Leukemia, Myeloid, Acute...) : CD40 and CD40L were minimally expressed on CD34 ( + ), CD34 ( - ) /CD33 ( + ), and CD34 ( - ) /CD33 ( - ) /CD15 ( + ) cells, but CD40 was substantially induced in the presence of TNF-a
Sun et al., Cancer Sci 2012 (Neoplasms) : These results reveal an important role of TNF-a induction in CD40 's chemosensitization activity and suggest that modulating TNF-a autocrine from cancer cells is an effective option for increasing the anticancer value of chemotherapeutics such as cisplatin
Lin et al., Cytokine 2012 : The combination treatment of resveratrol and PDTC significantly reduced TNF-a induced expression of CD40 , and the inhibitory effects were higher than that of the single treatment
Wu et al., J Lipid Res 2012 (Hyperlipidemias) : Abundance of miR-181a attenuated ox-LDL induced CD83 and CD40 expression, inhibited the secretion of interleukin (IL)-6 and TNF-a , and up-regulated IL-10, an important anti-inflammatory cytokine that was inhibited by ox-LDL
Gast et al., Brain Behav Immun 2013 (Autoimmune Diseases...) : Our study indicates that sleep-wake dysregulation in autoimmune diseases may result from CD40 induced TNF : TNFR1 mediated alterations of molecular pathways, which regulate sleep-wake behavior
Yang et al., Cell Physiol Biochem 2012 : The present study was thus designed to explore the potential effect of SIRT1 on CD40 expression induced by tumor necrosis factor-a (TNF-a) and to disclose the underlying mechanism in CRL-1730 endothelial cells ... Pretreatment with resveratrol ( a potent SIRT1 activator ) inhibited TNF-a induced CD40 expression, while pretreatment with nicotinamide ( class b HDACs inhibitor nicotinamide ) or sirtinol ( a known SIRT1 inhibitor ), especially SIRT1 siRNA significantly augmented TNF-a induced CD40 expression ... The frther sudy idicated that PDTC ( NF-?B inhibitor ) pretreatment attenuated TNF-a induced CD40 expression, and SIRT1 siRNA significantly augmented TNF-a induced acetylated-NF-?B p65 ( Lys310 ) expression ... Conclusion : The present study provides the direct evidence that SIRT1 can inhibit TNF-a- induced CD40 expression in CRL-1730 endothelial cells by deacetylating the RelA/p65 subunit of NF-?B at lysine 310, which provides new insights into understanding of the anti-inflammatory and anti-athroscerotic actions of SIRT1
Wang et al., Exp Cell Res 2013 : PPARa agonist fenofibrate attenuates TNF-a induced CD40 expression in 3T3-L1 adipocytes via the SIRT1 dependent signaling pathway
Xue et al., Int Immunopharmacol 2013 : We elucidated that IFN-? up-regulated the expression of MHC II, CD40 , CD80, CD83 and CD86 molecules on BMDCs, down-regulated the activity of pinocytosis and phagocytosis by BMDCs, and induced higher levels of IL-12 and TNF-a secreted by BMDCs
Ramsdell et al., J Immunol 1994 : In addition to proliferation, CD40L induces lectin mediated cytolytic activity in thymic gamma delta T cells as well as the production of IFN-gamma and TNF-alpha
Gruss et al., Blood 1994 (Hodgkin Disease...) : We found that recombinant CD40 ligand (CD40L) induced interleukin-8 (IL-8) secretion and enhanced IL-6, TNF , and lymphotoxin-alpha ( LT-alpha/TNF-beta ) release from cultured H-RS cells
Worm et al., Int Immunol 1994 : Induction of TNF-alpha mRNA was inhibited by actinomycin D suggesting that CD40 ligation results in transcriptional activation of the TNF-alpha and LT-alpha genes ... Anti-CD40 caused minimal increase in the expression of TNF-alpha on the B cell membrane and no detectable secretion of TNF-alpha
Thieblemont et al., J Immunol 1995 (HIV Infections) : TNF-alpha did not mediate the translocation of NF-kappa B p50/p65 induced by triggering of complement receptors
Ludewig et al., Eur J Immunol 1995 : Furthermore, IL-10 led to the down-regulation of various surface antigens, especially of CD86 and CD54, whereas TNF-alpha and TRAP enhanced the expression of MHC class I and II antigens and of the accessory molecules CD40 , CD54, CD80 and CD86
Tan et al., Biochim Biophys Acta 1994 : Our results indicate that both PAF and TNF stimulate the expression of NF-kappa B p50/p105 in vivo
McLellan et al., Eur J Immunol 1996 : However, CD40 was rapidly up-regulated by culture, and its expression was further enhanced by interleukin (IL)-1 alpha, IL-1 beta, IL-3, tumor necrosis factor-alpha and granulocyte/macrophage-colony stimulating factor
Drew et al., J Interferon Cytokine Res 1995 : We demonstrated here that TNF-alpha induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence ( ICS )
Péguet-Navarro et al., J Immunol 1997 : Using CD40-ligand transfected L cells (CD40Lc), we demonstrated that CD40 triggering results in an enhanced secretion of both IL-8 and TNF-alpha by cultured epidermal basal cells, suggesting that CD40-CD40L interactions may play a role in amplifying the cutaneous inflammatory reactions
Jakob et al., J Immunol 1998 : Flow cytometry of FSDDC-A revealed that IL-1, TNF-alpha , and LPS induced increased expression of MHC class II, CD40 , and CD86 and decreased E-cadherin expression that was temporally related to dissociation of aggregates
Sekine et al., J Rheumatol 1998 (Arthritis, Rheumatoid) : Involvement of CD40 in tumor necrosis factor-alpha (TNF-alpha) secretion from RA synovial fluid mononuclear cells ( SFMC ) was examined by blocking with anti-CD40 antibody
Iwasaki et al., Clin Exp Immunol 1998 : CD40 also augmented tumour necrosis factor-alpha (TNF-alpha) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) expression but resulted in decreased IL-10 expression
Lin et al., Exp Cell Res 1998 (Burkitt Lymphoma) : The inhibitory effect of anti-CD40 or TNF-alpha on anti-IgM induced apoptosis did not carry over to an effect on apoptosis induction by the CCS agents
Revy et al., Eur J Immunol 1998 (Immunologic Deficiency Syndromes) : We show that the CD40 induced production of IL-6, IL-8 and TNF-alpha by monocytes, and IL-12 by dendritic cells, and expression of the activation markers CD83, the costimulatory molecules CD86 and CD80, and HLA-DR antigens were all similar in patient and control cells
Snijders et al., Int Immunol 1998 : The two-signal requirement proved unique for the production of IL-12, since either CD40 engagement or LPS was sufficient for the efficient production of tumor necrosis factor-alpha , IL-8 and the p40 subunit of IL-12, and may be considered as a safety mechanism for optimal control of potentially harmful T ( h ) 1 responses