◀ Back to PPARGC1A

PPARGC1A — VEGFA

Text-mined interactions from Literome

Arany et al., Nature 2008 (Ischemia) : HIF independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha ... Here we show that the transcriptional coactivator PGC-1alpha ( peroxisome-proliferator activated receptor-gamma coactivator-1alpha ), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle in vivo ... Surprisingly, the induction of VEGF by PGC-1alpha does not involve the canonical hypoxia response pathway and hypoxia inducible factor ( HIF )
Chinsomboon et al., Proc Natl Acad Sci U S A 2009 (Peripheral Vascular Diseases) : The orphan nuclear receptor ERRalpha mediated the induction of VEGF by PGC-1alpha , and mice lacking ERRalpha also failed to increase vascular density after exercise