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DKK1 — TNFRSF11B

Text-mined interactions from Literome

Bu et al., Int J Cancer 2008 (Bone Neoplasms...) : Breast cancer derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression : implication for breast cancer osteolytic bone metastases
Gavriatopoulou et al., Expert Opin Ther Targets 2009 (Bone Diseases...) : In addition to its direct inhibitory effect of Dkk-1 on osteoblasts, Dkk-1 disrupts the Wnt3a regulated osteoprotegerin and receptor activator of NF-kappaB ligand ( RANKL ) expression in osteoblasts and thus it indirectly enhances osteoclast function in MM. Dkk-1 serum and bone marrow plasma levels are increased in MM patients and correlated with advanced International Staging System stage and presence of osteolytic lesions