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CD4 — IL15
Text-mined interactions from Literome
Lin et al., Pediatr Allergy Immunol 2001
:
Interleukin-15 enhances
CD4 ( + ) CD45RA ( + ) expression on umbilical cord blood mononuclear cells
Villinger et al., Vaccine 2004
:
IL-15 also significantly
enhanced early and late TT specific
CD4 responses
Picker et al., J Clin Invest 2006
(HIV Infections...) :
IL-15 induces
CD4 effector memory T cell production and tissue emigration in nonhuman primates
Pepe et al., Curr Pharm Des 2006
:
This Th1 polarizing activity is mediated by
interleukin-12 released by infected CDs in the
presence of
CD4 ( + ) cells
Ariga et al., Immunology 2007
:
Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive
CD4 ( + ) T cells
induces transient T-bet expression,
interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Fan et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007
(Autoimmune Diseases) :
IL-23, IL-2 and
IL-15 can directly
induce CD4 ( + ) T cells to produce IL-17 and IFN-gamma
Patterson et al., Virology 2008
(HIV Infections) :
Both IL-2 and
IL-15 increased cytomegalovirus induced
CD4+ and CD8+ T-cell proliferation and the synthesis of Th1 and pro-inflammatory cytokines and chemokines
Zhu et al., Gastroenterology 2010
(Eosinophilia...) :
IL-15 activated STAT5 and
CD4 ( + ) T cells to produce cytokines that act on eosinophils ...
IL-15 activates
CD4 ( + ) T cells to produce cytokines that act on eosinophils
Zhang et al., J Leukoc Biol 2010
:
CpG treated, CD4-8- DCOVA secreting
IL-6/IL-15 induced IFN-gamma/IL-17-secreting/T-bet- and ROR-gammat expressing
CD4+ Th1/Th17, whereas LPS treated CD4-8- DCOVA stimulated IFN-gamma-secreting/T-bet expressing CD4+ Th1 responses
Tripathi et al., J Immunol 2010
(Lymphocytic Choriomeningitis) :
In this study, we assessed the
role of IL-7,
IL-15 , and their common signal transducer, STAT5, in maintaining effector
CD4 ( + ) and CD8 ( + ) T cell responses ... In contrast, effector
CD4 ( + ) T cell numbers were not
affected by the individual or combined loss of
IL-15 and IL-7
Vandergeeten et al., Blood 2013
(HIV Infections) :
When administered to HIV infected subjects receiving suppressive ART,
interleukin-7 (IL-7)
increases the number of
CD4 ( + ) T cells by promoting their survival and proliferation
Suzuki et al., J Virol 1999
:
Among them,
interleukin-12 (IL-12) and IL-4
induce naive
CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively