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CBL — IGF1R

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CBL-SORBS1 → IGF1R (increases, IGF1R Translocation, CBL/SORBS1 Activity)
  Evidence: Upon phosphorylation, the Cbl-CAP complex translocates to lipid raft domains in the plasma membrane, mediated by the interaction of the SoHo domain of CAP with the protein flotillin50.
• KEGG Endocytosis: CBL/CBLB/CBLC/ITCH/MDM2/NEDD4/NEDD4L/RNF41/SMURF1/SMURF2/TRAF6/WWP1 → CSF1R/EGFR/ERBB3/ERBB4/FGFR2/FGFR3/FGFR4/FLT1/IGF1R/KDR/KIT/MET/NTRK1/PDGFRA/RET (protein-protein, ubiquination)
  
• WikiPathways Signaling Pathways in Glioblastoma: CBL → IGF1R/ERBB3/FGFR1/PDGFRA/PDGFRB/ERBB2/EGFR/FGFR2/MET (mim-inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IGF1R — CBL (physical association, affinity chromatography technology) Sehat et al., Cancer Res 2008
• IRef Biogrid Interaction: IGF1R — CBL (direct interaction, enzymatic study) Sehat et al., Cancer Res 2008
• IRef Hprd Interaction: IGF1R — CBL (in vivo) Sehat et al., Cancer Res 2008
• IRef Hprd Interaction: IGF1R — CBL (in vitro) Sehat et al., Cancer Res 2008